PbN db.11x8.5: P A I N K I L L E R

A D V E R T I S E M E N T

CLPQ motif Ca2+-mediated cell-cell Cmyb_C Cyanobacterium FMR2 nuclear proteins GUN4 AF-4 proto-oncoprotein AF4 protein EF hand-like Cbl FAT-family cadherin7th position alpha helix AAA VWA C-terminus FMR2 nuclear proteins GUN4 Cmyb_C Cyanobacterium FMR2 nuclear proteins GUN47th position alpha helix AAA VWA C-terminus C-terminal CA Cadherin AT-hook domain C-myb Mg-Proto Mg-chelatase (hetero- and homo-) 3 structural Cbl_N2 C-terminal CA Cadherin (hetero- and homo-) 3 structural Cbl_N2 (hetero- and homo-) 3 structural Cbl_N2 Mg-Proto Mg-chelatase GUN4 plastid GUN4-like Arabidopsis (hetero- and homo-) 3 structural Cbl_N2 CBL N-terminus CBL receptors SH3 Mg-Proto Mg-chelatase AF-4 proto-oncoprotein AF4 protein AF-4 proto-oncoprotein AF4 protein Cmyb_C Cyanobacterium DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase Cmyb_C Cyanobacterium DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase C-terminal CA Cadherin EF hand-like Cbl FAT-family cadherin (Proto-oncogene AF4) (b-HLH-lz) Max GUN4 plastid GUN4-like Arabidopsis C-terminal CA Cadherin AT-hook domain C-myb Cmyb_C Cyanobacterium DNA binding Myc-Max Drosophila (Proto-oncogene AF4) (b-HLH-lz) Max AF-4 proto-oncoprotein AF4 protein Mg-Proto Mg-chelatase Mg-chelatase catalyses insertion (Proto-oncogene AF4) (b-HLH-lz) Max EF hand-like Cbl FAT-family cadherin Mg-Proto Mg-chelatase CBL N-terminus CBL receptors SH3 Cmyb_C Cyanobacterium CLPQ motif Ca2+-mediated cell-cell7th position alpha helix AAA VWA C-terminus Cmyb_C Cyanobacterium7th position alpha helix AAA VWA C-terminus AT-hook domain C-myb (Proto-oncogene AF4) (b-HLH-lz) Max AF-4 proto-oncoprotein AF4 protein CLPQ motif Ca2+-mediated cell-cell Cmyb_C Cyanobacterium Helianthus annuus Magnesium chelatase AT-hook domain C-myb CBL N-terminus CBL receptors SH3 Cmyb_C Cyanobacterium Helianthus annuus Magnesium chelatase (hetero- and homo-) 3 structural Cbl_N2 CBL N-terminus CBL receptors SH3 Mg-Proto Mg-chelatase

AF-4 proto-oncoprotein AF4 protein (hetero- and homo-) 3 structural Cbl_N2 C-terminal CA Cadherin EF hand-like Cbl FAT-family cadherin CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase FMR2 nuclear proteins GUN4 CLPQ motif Ca2+-mediated cell-cell Cmyb_C Cyanobacterium AT-hook domain C-myb Cmyb_C Cyanobacterium AT-hook domain C-myb Mg-Proto Mg-chelatase FMR2 nuclear proteins GUN4 Mg-chelatase catalyses insertion Helianthus annuus Magnesium chelatase (Proto-oncogene AF4) (b-HLH-lz) Max AT-hook domain C-myb7th position alpha helix AAA VWA C-terminus (Proto-oncogene AF4) (b-HLH-lz) Max AF-4 proto-oncoprotein AF4 protein Helianthus annuus Magnesium chelatase AF-4 proto-oncoprotein AF4 protein AF-4 proto-oncoprotein AF4 protein Mg-chelatase catalyses insertion7th position alpha helix AAA VWA C-terminus CLPQ motif Ca2+-mediated cell-cell (hetero- and homo-) 3 structural Cbl_N2 CLPQ motif Ca2+-mediated cell-cell Cmyb_C Cyanobacterium EF hand-like Cbl FAT-family cadherin CBL N-terminus CBL receptors SH3 Mg-chelatase catalyses insertion7th position alpha helix AAA VWA C-terminus (Proto-oncogene AF4) (b-HLH-lz) Max7th position alpha helix AAA VWA C-terminus Mg-chelatase catalyses insertion FMR2 nuclear proteins GUN4 Mg-Proto Mg-chelatase C-terminal CA Cadherin EF hand-like Cbl FAT-family cadherin7th position alpha helix AAA VWA C-terminus CBL N-terminus CBL receptors SH3 Mg-Proto Mg-chelatase Mg-Proto Mg-chelatase CBL N-terminus CBL receptors SH3 CBL N-terminus CBL receptors SH3 CBL N-terminus CBL receptors SH3 DNA binding Myc-Max Drosophila (Proto-oncogene AF4) (b-HLH-lz) Max (Proto-oncogene AF4) (b-HLH-lz) Max Mg-Proto Mg-chelatase AF-4 proto-oncoprotein AF4 protein EF hand-like Cbl FAT-family cadherin GUN4 plastid GUN4-like Arabidopsis Mg-chelatase catalyses insertion (Proto-oncogene AF4) (b-HLH-lz) Max (Proto-oncogene AF4) (b-HLH-lz) Max EF hand-like Cbl FAT-family cadherin AF-4 proto-oncoprotein AF4 protein GUN4 plastid GUN4-like Arabidopsis FMR2 nuclear proteins GUN4 C-terminal CA Cadherin FMR2 nuclear proteins GUN4

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Helianthus annuus Magnesium chelatase GUN4 plastid GUN4-like Arabidopsis Helianthus annuus Magnesium chelatase AT-hook domain C-myb AF-4 proto-oncoprotein AF4 protein AF-4 proto-oncoprotein AF4 protein Mg-chelatase catalyses insertion AF-4 proto-oncoprotein AF4 protein (Proto-oncogene AF4) (b-HLH-lz) Max GUN4 plastid GUN4-like Arabidopsis Helianthus annuus Magnesium chelatase DNA binding Myc-Max Drosophila GUN4 plastid GUN4-like Arabidopsis (hetero- and homo-) 3 structural Cbl_N2 Cmyb_C Cyanobacterium Cmyb_C Cyanobacterium EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb C-terminal CA Cadherin Mg-chelatase catalyses insertion EF hand-like Cbl FAT-family cadherin CBL N-terminus CBL receptors SH3 Mg-Proto Mg-chelatase C-terminal CA Cadherin CLPQ motif Ca2+-mediated cell-cell DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase EF hand-like Cbl FAT-family cadherin7th position alpha helix AAA VWA C-terminus CBL N-terminus CBL receptors SH3 Mg-chelatase catalyses insertion EF hand-like Cbl FAT-family cadherin Mg-Proto Mg-chelatase EF hand-like Cbl FAT-family cadherin CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase AT-hook domain C-myb Cmyb_C Cyanobacterium AT-hook domain C-myb C-terminal CA Cadherin (Proto-oncogene AF4) (b-HLH-lz) Max AT-hook domain C-myb Mg-Proto Mg-chelatase GUN4 plastid GUN4-like Arabidopsis GUN4 plastid GUN4-like Arabidopsis (hetero- and homo-) 3 structural Cbl_N2 (Proto-oncogene AF4) (b-HLH-lz) Max7th position alpha helix AAA VWA C-terminus (hetero- and homo-) 3 structural Cbl_N2 FMR2 nuclear proteins GUN4 AT-hook domain C-myb CBL N-terminus CBL receptors SH3 GUN4 plastid GUN4-like Arabidopsis EF hand-like Cbl FAT-family cadherin Mg-Proto Mg-chelatase (hetero- and homo-) 3 structural Cbl_N2 AT-hook domain C-myb Mg-Proto Mg-chelatase AF-4 proto-oncoprotein AF4 protein FMR2 nuclear proteins GUN47th position alpha helix AAA VWA C-terminus Helianthus annuus Magnesium chelatase EF hand-like Cbl FAT-family cadherin Cmyb_C Cyanobacterium

AF-4 proto-oncoprotein AF4 protein EF hand-like Cbl FAT-family cadherin AF-4 proto-oncoprotein AF4 protein EF hand-like Cbl FAT-family cadherin CBL N-terminus CBL receptors SH37th position alpha helix AAA VWA C-terminus DNA binding Myc-Max Drosophila Cmyb_C Cyanobacterium C-terminal CA Cadherin C-terminal CA Cadherin AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis7th position alpha helix AAA VWA C-terminus Helianthus annuus Magnesium chelatase C-terminal CA Cadherin Mg-Proto Mg-chelatase Mg-chelatase catalyses insertion Helianthus annuus Magnesium chelatase7th position alpha helix AAA VWA C-terminus7th position alpha helix AAA VWA C-terminus CBL N-terminus CBL receptors SH3 DNA binding Myc-Max Drosophila AF-4 proto-oncoprotein AF4 protein GUN4 plastid GUN4-like Arabidopsis Cmyb_C Cyanobacterium FMR2 nuclear proteins GUN4 DNA binding Myc-Max Drosophila Mg-Proto Mg-chelatase Mg-Proto Mg-chelatase AF-4 proto-oncoprotein AF4 protein DNA binding Myc-Max Drosophila DNA binding Myc-Max Drosophila GUN4 plastid GUN4-like Arabidopsis DNA binding Myc-Max Drosophila AF-4 proto-oncoprotein AF4 protein GUN4 plastid GUN4-like Arabidopsis AT-hook domain C-myb CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase Mg-Proto Mg-chelatase DNA binding Myc-Max Drosophila CBL N-terminus CBL receptors SH3 DNA binding Myc-Max Drosophila CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase Helianthus annuus Magnesium chelatase Mg-chelatase catalyses insertion Mg-Proto Mg-chelatase CLPQ motif Ca2+-mediated cell-cell C-terminal CA Cadherin Mg-Proto Mg-chelatase (hetero- and homo-) 3 structural Cbl_N27th position alpha helix AAA VWA C-terminus Helianthus annuus Magnesium chelatase Cmyb_C Cyanobacterium AT-hook domain C-myb (Proto-oncogene AF4) (b-HLH-lz) Max Mg-chelatase catalyses insertion (Proto-oncogene AF4) (b-HLH-lz) Max CLPQ motif Ca2+-mediated cell-cell Mg-Proto Mg-chelatase DNA binding Myc-Max Drosophila AF-4 proto-oncoprotein AF4 protein7th position alpha helix AAA VWA C-terminus

EF hand-like Cbl FAT-family cadherin DNA binding Myc-Max Drosophila CBL N-terminus CBL receptors SH3 AT-hook domain C-myb AF-4 proto-oncoprotein AF4 protein C-terminal CA Cadherin Mg-Proto Mg-chelatase EF hand-like Cbl FAT-family cadherin CLPQ motif Ca2+-mediated cell-cell GUN4 plastid GUN4-like Arabidopsis EF hand-like Cbl FAT-family cadherin FMR2 nuclear proteins GUN4 Helianthus annuus Magnesium chelatase Mg-Proto Mg-chelatase CLPQ motif Ca2+-mediated cell-cell7th position alpha helix AAA VWA C-terminus EF hand-like Cbl FAT-family cadherin CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase CBL N-terminus CBL receptors SH37th position alpha helix AAA VWA C-terminus (hetero- and homo-) 3 structural Cbl_N2 AF-4 proto-oncoprotein AF4 protein AF-4 proto-oncoprotein AF4 protein GUN4 plastid GUN4-like Arabidopsis (Proto-oncogene AF4) (b-HLH-lz) Max CLPQ motif Ca2+-mediated cell-cell AF-4 proto-oncoprotein AF4 protein (hetero- and homo-) 3 structural Cbl_N2 AF-4 proto-oncoprotein AF4 protein DNA binding Myc-Max Drosophila (Proto-oncogene AF4) (b-HLH-lz) Max7th position alpha helix AAA VWA C-terminus (hetero- and homo-) 3 structural Cbl_N2 GUN4 plastid GUN4-like Arabidopsis AT-hook domain C-myb FMR2 nuclear proteins GUN4 (hetero- and homo-) 3 structural Cbl_N27th position alpha helix AAA VWA C-terminus7th position alpha helix AAA VWA C-terminus7th position alpha helix AAA VWA C-terminus CLPQ motif Ca2+-mediated cell-cell (Proto-oncogene AF4) (b-HLH-lz) Max C-terminal CA Cadherin (Proto-oncogene AF4) (b-HLH-lz) Max FMR2 nuclear proteins GUN4 GUN4 plastid GUN4-like Arabidopsis GUN4 plastid GUN4-like Arabidopsis Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N2 CBL N-terminus CBL receptors SH3 AT-hook domain C-myb Cmyb_C Cyanobacterium CLPQ motif Ca2+-mediated cell-cell Mg-Proto Mg-chelatase FMR2 nuclear proteins GUN4 AT-hook domain C-myb AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis7th position alpha helix AAA VWA C-terminus (hetero- and homo-) 3 structural Cbl_N2 Mg-chelatase catalyses insertion CLPQ motif Ca2+-mediated cell-cell CLPQ motif Ca2+-mediated cell-cell

EF hand-like Cbl FAT-family cadherin7th position alpha helix AAA VWA C-terminus (hetero- and homo-) 3 structural Cbl_N2 Cmyb_C Cyanobacterium EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb (Proto-oncogene AF4) (b-HLH-lz) Max (Proto-oncogene AF4) (b-HLH-lz) Max DNA binding Myc-Max Drosophila AF-4 proto-oncoprotein AF4 protein (Proto-oncogene AF4) (b-HLH-lz) Max DNA binding Myc-Max Drosophila AT-hook domain C-myb CBL N-terminus CBL receptors SH3 (Proto-oncogene AF4) (b-HLH-lz) Max AF-4 proto-oncoprotein AF4 protein Cmyb_C Cyanobacterium AT-hook domain C-myb EF hand-like Cbl FAT-family cadherin Mg-chelatase catalyses insertion C-terminal CA Cadherin Mg-chelatase catalyses insertion (Proto-oncogene AF4) (b-HLH-lz) Max (hetero- and homo-) 3 structural Cbl_N2 CLPQ motif Ca2+-mediated cell-cell CBL N-terminus CBL receptors SH3 CBL N-terminus CBL receptors SH3 GUN4 plastid GUN4-like Arabidopsis Mg-Proto Mg-chelatase GUN4 plastid GUN4-like Arabidopsis Mg-chelatase catalyses insertion FMR2 nuclear proteins GUN4 Mg-Proto Mg-chelatase7th position alpha helix AAA VWA C-terminus C-terminal CA Cadherin DNA binding Myc-Max Drosophila FMR2 nuclear proteins GUN4 (Proto-oncogene AF4) (b-HLH-lz) Max DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase AF-4 proto-oncoprotein AF4 protein (hetero- and homo-) 3 structural Cbl_N2 AF-4 proto-oncoprotein AF4 protein AF-4 proto-oncoprotein AF4 protein EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb Mg-Proto Mg-chelatase CLPQ motif Ca2+-mediated cell-cell AT-hook domain C-myb AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis C-terminal CA Cadherin Cmyb_C Cyanobacterium (Proto-oncogene AF4) (b-HLH-lz) Max7th position alpha helix AAA VWA C-terminus DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase (Proto-oncogene AF4) (b-HLH-lz) Max EF hand-like Cbl FAT-family cadherin Mg-Proto Mg-chelatase7th position alpha helix AAA VWA C-terminus GUN4 plastid GUN4-like Arabidopsis

GUN4 plastid GUN4-like Arabidopsis Helianthus annuus Magnesium chelatase GUN4 plastid GUN4-like Arabidopsis Helianthus annuus Magnesium chelatase CBL N-terminus CBL receptors SH3 AT-hook domain C-myb Mg-Proto Mg-chelatase GUN4 plastid GUN4-like Arabidopsis GUN4 plastid GUN4-like Arabidopsis (Proto-oncogene AF4) (b-HLH-lz) Max Mg-Proto Mg-chelatase Mg-Proto Mg-chelatase AF-4 proto-oncoprotein AF4 protein FMR2 nuclear proteins GUN4 Mg-chelatase catalyses insertion Helianthus annuus Magnesium chelatase (Proto-oncogene AF4) (b-HLH-lz) Max DNA binding Myc-Max Drosophila AT-hook domain C-myb Mg-chelatase catalyses insertion AF-4 proto-oncoprotein AF4 protein Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N2 Mg-Proto Mg-chelatase Cmyb_C Cyanobacterium Mg-chelatase catalyses insertion7th position alpha helix AAA VWA C-terminus Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N2 CLPQ motif Ca2+-mediated cell-cell DNA binding Myc-Max Drosophila Cmyb_C Cyanobacterium Cmyb_C Cyanobacterium7th position alpha helix AAA VWA C-terminus (Proto-oncogene AF4) (b-HLH-lz) Max DNA binding Myc-Max Drosophila AF-4 proto-oncoprotein AF4 protein GUN4 plastid GUN4-like Arabidopsis Mg-chelatase catalyses insertion FMR2 nuclear proteins GUN4 EF hand-like Cbl FAT-family cadherin (hetero- and homo-) 3 structural Cbl_N2 Mg-chelatase catalyses insertion GUN4 plastid GUN4-like Arabidopsis (Proto-oncogene AF4) (b-HLH-lz) Max Mg-chelatase catalyses insertion Cmyb_C Cyanobacterium AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis Cmyb_C Cyanobacterium (hetero- and homo-) 3 structural Cbl_N2 Mg-Proto Mg-chelatase CLPQ motif Ca2+-mediated cell-cell EF hand-like Cbl FAT-family cadherin Mg-Proto Mg-chelatase DNA binding Myc-Max Drosophila FMR2 nuclear proteins GUN4 CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase GUN4 plastid GUN4-like Arabidopsis Helianthus annuus Magnesium chelatase CLPQ motif Ca2+-mediated cell-cell GUN4 plastid GUN4-like Arabidopsis (Proto-oncogene AF4) (b-HLH-lz) Max

C-terminal CA Cadherin (Proto-oncogene AF4) (b-HLH-lz) Max CBL N-terminus CBL receptors SH37th position alpha helix AAA VWA C-terminus EF hand-like Cbl FAT-family cadherin Cmyb_C Cyanobacterium AF-4 proto-oncoprotein AF4 protein EF hand-like Cbl FAT-family cadherin Mg-Proto Mg-chelatase Mg-Proto Mg-chelatase AF-4 proto-oncoprotein AF4 protein CLPQ motif Ca2+-mediated cell-cell AF-4 proto-oncoprotein AF4 protein Helianthus annuus Magnesium chelatase C-terminal CA Cadherin AF-4 proto-oncoprotein AF4 protein (Proto-oncogene AF4) (b-HLH-lz) Max C-terminal CA Cadherin CBL N-terminus CBL receptors SH3 DNA binding Myc-Max Drosophila AT-hook domain C-myb Mg-chelatase catalyses insertion CBL N-terminus CBL receptors SH3 EF hand-like Cbl FAT-family cadherin Mg-chelatase catalyses insertion AF-4 proto-oncoprotein AF4 protein Mg-Proto Mg-chelatase (hetero- and homo-) 3 structural Cbl_N2 AT-hook domain C-myb Cmyb_C Cyanobacterium7th position alpha helix AAA VWA C-terminus Cmyb_C Cyanobacterium Cmyb_C Cyanobacterium EF hand-like Cbl FAT-family cadherin GUN4 plastid GUN4-like Arabidopsis Mg-Proto Mg-chelatase FMR2 nuclear proteins GUN4 Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N2 CBL N-terminus CBL receptors SH3 DNA binding Myc-Max Drosophila C-terminal CA Cadherin Mg-Proto Mg-chelatase CBL N-terminus CBL receptors SH3 FMR2 nuclear proteins GUN4 AT-hook domain C-myb Mg-chelatase catalyses insertion (Proto-oncogene AF4) (b-HLH-lz) Max AF-4 proto-oncoprotein AF4 protein CLPQ motif Ca2+-mediated cell-cell AT-hook domain C-myb CLPQ motif Ca2+-mediated cell-cell AF-4 proto-oncoprotein AF4 protein AF-4 proto-oncoprotein AF4 protein AT-hook domain C-myb Mg-chelatase catalyses insertion Mg-Proto Mg-chelatase C-terminal CA Cadherin DNA binding Myc-Max Drosophila DNA binding Myc-Max Drosophila AF-4 proto-oncoprotein AF4 protein CLPQ motif Ca2+-mediated cell-cell FMR2 nuclear proteins GUN4 Cmyb_C Cyanobacterium

CLPQ motif Ca2+-mediated cell-cell Helianthus annuus Magnesium chelatase AT-hook domain C-myb AF-4 proto-oncoprotein AF4 protein C-terminal CA Cadherin FMR2 nuclear proteins GUN4 Mg-Proto Mg-chelatase Cmyb_C Cyanobacterium EF hand-like Cbl FAT-family cadherin DNA binding Myc-Max Drosophila7th position alpha helix AAA VWA C-terminus GUN4 plastid GUN4-like Arabidopsis Mg-chelatase catalyses insertion FMR2 nuclear proteins GUN4 DNA binding Myc-Max Drosophila AT-hook domain C-myb CBL N-terminus CBL receptors SH37th position alpha helix AAA VWA C-terminus C-terminal CA Cadherin FMR2 nuclear proteins GUN4 AF-4 proto-oncoprotein AF4 protein GUN4 plastid GUN4-like Arabidopsis Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N2 CBL N-terminus CBL receptors SH3 Cmyb_C Cyanobacterium AT-hook domain C-myb7th position alpha helix AAA VWA C-terminus EF hand-like Cbl FAT-family cadherin AF-4 proto-oncoprotein AF4 protein DNA binding Myc-Max Drosophila Mg-chelatase catalyses insertion GUN4 plastid GUN4-like Arabidopsis CLPQ motif Ca2+-mediated cell-cell CBL N-terminus CBL receptors SH3 C-terminal CA Cadherin (Proto-oncogene AF4) (b-HLH-lz) Max AF-4 proto-oncoprotein AF4 protein C-terminal CA Cadherin CLPQ motif Ca2+-mediated cell-cell FMR2 nuclear proteins GUN4 Cmyb_C Cyanobacterium Mg-Proto Mg-chelatase CBL N-terminus CBL receptors SH3 Cmyb_C Cyanobacterium Cmyb_C Cyanobacterium GUN4 plastid GUN4-like Arabidopsis FMR2 nuclear proteins GUN47th position alpha helix AAA VWA C-terminus EF hand-like Cbl FAT-family cadherin EF hand-like Cbl FAT-family cadherin Mg-Proto Mg-chelatase Mg-Proto Mg-chelatase AF-4 proto-oncoprotein AF4 protein Mg-Proto Mg-chelatase Helianthus annuus Magnesium chelatase CLPQ motif Ca2+-mediated cell-cell Mg-Proto Mg-chelatase Mg-Proto Mg-chelatase Helianthus annuus Magnesium chelatase CBL N-terminus CBL receptors SH3 Mg-Proto Mg-chelatase EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb

Cmyb_C Cyanobacterium AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis (hetero- and homo-) 3 structural Cbl_N2 Mg-chelatase catalyses insertion C-terminal CA Cadherin C-terminal CA Cadherin GUN4 plastid GUN4-like Arabidopsis Mg-chelatase catalyses insertion EF hand-like Cbl FAT-family cadherin7th position alpha helix AAA VWA C-terminus DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase DNA binding Myc-Max Drosophila GUN4 plastid GUN4-like Arabidopsis EF hand-like Cbl FAT-family cadherin EF hand-like Cbl FAT-family cadherin (hetero- and homo-) 3 structural Cbl_N2 CBL N-terminus CBL receptors SH3 AT-hook domain C-myb CLPQ motif Ca2+-mediated cell-cell (Proto-oncogene AF4) (b-HLH-lz) Max Mg-Proto Mg-chelatase (Proto-oncogene AF4) (b-HLH-lz) Max FMR2 nuclear proteins GUN4 (hetero- and homo-) 3 structural Cbl_N2 Cmyb_C Cyanobacterium FMR2 nuclear proteins GUN4 Mg-Proto Mg-chelatase AT-hook domain C-myb Cmyb_C Cyanobacterium C-terminal CA Cadherin Mg-chelatase catalyses insertion DNA binding Myc-Max Drosophila Mg-Proto Mg-chelatase Mg-Proto Mg-chelatase C-terminal CA Cadherin (Proto-oncogene AF4) (b-HLH-lz) Max FMR2 nuclear proteins GUN4 CBL N-terminus CBL receptors SH3 AT-hook domain C-myb Mg-Proto Mg-chelatase (Proto-oncogene AF4) (b-HLH-lz) Max FMR2 nuclear proteins GUN4 AF-4 proto-oncoprotein AF4 protein Helianthus annuus Magnesium chelatase Cmyb_C Cyanobacterium Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N2 (Proto-oncogene AF4) (b-HLH-lz) Max AT-hook domain C-myb (Proto-oncogene AF4) (b-HLH-lz) Max AT-hook domain C-myb (Proto-oncogene AF4) (b-HLH-lz) Max Cmyb_C Cyanobacterium AT-hook domain C-myb AF-4 proto-oncoprotein AF4 protein CBL N-terminus CBL receptors SH3 (Proto-oncogene AF4) (b-HLH-lz) Max DNA binding Myc-Max Drosophila GUN4 plastid GUN4-like Arabidopsis GUN4 plastid GUN4-like Arabidopsis CLPQ motif Ca2+-mediated cell-cell C-terminal CA Cadherin

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EF hand-like Cbl FAT-family cadherin Cmyb_C Cyanobacterium AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis CLPQ motif Ca2+-mediated cell-cell C-terminal CA Cadherin (hetero- and homo-) 3 structural Cbl_N2 Cmyb_C Cyanobacterium (hetero- and homo-) 3 structural Cbl_N2 Helianthus annuus Magnesium chelatase Mg-Proto Mg-chelatase C-terminal CA Cadherin Cmyb_C Cyanobacterium Cmyb_C Cyanobacterium7th position alpha helix AAA VWA C-terminus (Proto-oncogene AF4) (b-HLH-lz) Max (hetero- and homo-) 3 structural Cbl_N2 Mg-chelatase catalyses insertion Mg-chelatase catalyses insertion Cmyb_C Cyanobacterium FMR2 nuclear proteins GUN4 Mg-chelatase catalyses insertion EF hand-like Cbl FAT-family cadherin (hetero- and homo-) 3 structural Cbl_N2 GUN4 plastid GUN4-like Arabidopsis CBL N-terminus CBL receptors SH3 CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase EF hand-like Cbl FAT-family cadherin Mg-chelatase catalyses insertion7th position alpha helix AAA VWA C-terminus C-terminal CA Cadherin GUN4 plastid GUN4-like Arabidopsis CLPQ motif Ca2+-mediated cell-cell CBL N-terminus CBL receptors SH3 C-terminal CA Cadherin (hetero- and homo-) 3 structural Cbl_N2 CBL N-terminus CBL receptors SH3 FMR2 nuclear proteins GUN4 EF hand-like Cbl FAT-family cadherin Mg-Proto Mg-chelatase AF-4 proto-oncoprotein AF4 protein Cmyb_C Cyanobacterium (hetero- and homo-) 3 structural Cbl_N2 AF-4 proto-oncoprotein AF4 protein Cmyb_C Cyanobacterium (Proto-oncogene AF4) (b-HLH-lz) Max Helianthus annuus Magnesium chelatase Cmyb_C Cyanobacterium C-terminal CA Cadherin (hetero- and homo-) 3 structural Cbl_N2 CLPQ motif Ca2+-mediated cell-cell Helianthus annuus Magnesium chelatase7th position alpha helix AAA VWA C-terminus Cmyb_C Cyanobacterium7th position alpha helix AAA VWA C-terminus CLPQ motif Ca2+-mediated cell-cell DNA binding Myc-Max Drosophila DNA binding Myc-Max Drosophila AF-4 proto-oncoprotein AF4 protein EF hand-like Cbl FAT-family cadherin Mg-chelatase catalyses insertion AF-4 proto-oncoprotein AF4 protein FMR2 nuclear proteins GUN4

7th position alpha helix AAA VWA C-terminus DNA binding Myc-Max Drosophila GUN4 plastid GUN4-like Arabidopsis Helianthus annuus Magnesium chelatase C-terminal CA Cadherin C-terminal CA Cadherin7th position alpha helix AAA VWA C-terminus CLPQ motif Ca2+-mediated cell-cell CBL N-terminus CBL receptors SH3 (hetero- and homo-) 3 structural Cbl_N2 Cmyb_C Cyanobacterium AF-4 proto-oncoprotein AF4 protein AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis Mg-chelatase catalyses insertion Mg-chelatase catalyses insertion FMR2 nuclear proteins GUN4 CLPQ motif Ca2+-mediated cell-cell DNA binding Myc-Max Drosophila (Proto-oncogene AF4) (b-HLH-lz) Max AF-4 proto-oncoprotein AF4 protein7th position alpha helix AAA VWA C-terminus C-terminal CA Cadherin (Proto-oncogene AF4) (b-HLH-lz) Max EF hand-like Cbl FAT-family cadherin (hetero- and homo-) 3 structural Cbl_N2 AT-hook domain C-myb7th position alpha helix AAA VWA C-terminus CBL N-terminus CBL receptors SH3 AF-4 proto-oncoprotein AF4 protein7th position alpha helix AAA VWA C-terminus AT-hook domain C-myb (hetero- and homo-) 3 structural Cbl_N2 AT-hook domain C-myb EF hand-like Cbl FAT-family cadherin (hetero- and homo-) 3 structural Cbl_N2 CBL N-terminus CBL receptors SH3 CBL N-terminus CBL receptors SH3 DNA binding Myc-Max Drosophila (Proto-oncogene AF4) (b-HLH-lz) Max Cmyb_C Cyanobacterium Mg-chelatase catalyses insertion CBL N-terminus CBL receptors SH3 DNA binding Myc-Max Drosophila FMR2 nuclear proteins GUN4 CLPQ motif Ca2+-mediated cell-cell CLPQ motif Ca2+-mediated cell-cell GUN4 plastid GUN4-like Arabidopsis CBL N-terminus CBL receptors SH3 EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis GUN4 plastid GUN4-like Arabidopsis (Proto-oncogene AF4) (b-HLH-lz) Max AF-4 proto-oncoprotein AF4 protein AF-4 proto-oncoprotein AF4 protein CBL N-terminus CBL receptors SH3 CLPQ motif Ca2+-mediated cell-cell Mg-chelatase catalyses insertion (Proto-oncogene AF4) (b-HLH-lz) Max Cmyb_C Cyanobacterium CLPQ motif Ca2+-mediated cell-cell Mg-Proto Mg-chelatase CBL N-terminus CBL receptors SH3

C-terminal CA Cadherin Cmyb_C Cyanobacterium C-terminal CA Cadherin AF-4 proto-oncoprotein AF4 protein C-terminal CA Cadherin (hetero- and homo-) 3 structural Cbl_N2 Helianthus annuus Magnesium chelatase (hetero- and homo-) 3 structural Cbl_N2 AT-hook domain C-myb CBL N-terminus CBL receptors SH3 Cmyb_C Cyanobacterium EF hand-like Cbl FAT-family cadherin CBL N-terminus CBL receptors SH3 FMR2 nuclear proteins GUN4 C-terminal CA Cadherin CBL N-terminus CBL receptors SH3 AT-hook domain C-myb Cmyb_C Cyanobacterium CBL N-terminus CBL receptors SH3 CLPQ motif Ca2+-mediated cell-cell GUN4 plastid GUN4-like Arabidopsis EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb DNA binding Myc-Max Drosophila CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase Helianthus annuus Magnesium chelatase Cmyb_C Cyanobacterium GUN4 plastid GUN4-like Arabidopsis GUN4 plastid GUN4-like Arabidopsis (Proto-oncogene AF4) (b-HLH-lz) Max Mg-chelatase catalyses insertion (Proto-oncogene AF4) (b-HLH-lz) Max Cmyb_C Cyanobacterium (hetero- and homo-) 3 structural Cbl_N27th position alpha helix AAA VWA C-terminus GUN4 plastid GUN4-like Arabidopsis (hetero- and homo-) 3 structural Cbl_N2 CLPQ motif Ca2+-mediated cell-cell Helianthus annuus Magnesium chelatase (hetero- and homo-) 3 structural Cbl_N2 Mg-chelatase catalyses insertion Mg-chelatase catalyses insertion CLPQ motif Ca2+-mediated cell-cell DNA binding Myc-Max Drosophila C-terminal CA Cadherin Helianthus annuus Magnesium chelatase FMR2 nuclear proteins GUN4 Mg-chelatase catalyses insertion FMR2 nuclear proteins GUN4 (hetero- and homo-) 3 structural Cbl_N2 C-terminal CA Cadherin CBL N-terminus CBL receptors SH3 Cmyb_C Cyanobacterium FMR2 nuclear proteins GUN4 Cmyb_C Cyanobacterium Helianthus annuus Magnesium chelatase CLPQ motif Ca2+-mediated cell-cell C-terminal CA Cadherin GUN4 plastid GUN4-like Arabidopsis Helianthus annuus Magnesium chelatase Cmyb_C Cyanobacterium (hetero- and homo-) 3 structural Cbl_N2 Cmyb_C Cyanobacterium

Mg-chelatase catalyses insertion Cmyb_C Cyanobacterium Cmyb_C Cyanobacterium EF hand-like Cbl FAT-family cadherin C-terminal CA Cadherin Helianthus annuus Magnesium chelatase (Proto-oncogene AF4) (b-HLH-lz) Max AT-hook domain C-myb FMR2 nuclear proteins GUN4 AF-4 proto-oncoprotein AF4 protein Mg-Proto Mg-chelatase (hetero- and homo-) 3 structural Cbl_N2 DNA binding Myc-Max Drosophila DNA binding Myc-Max Drosophila Mg-chelatase catalyses insertion AT-hook domain C-myb EF hand-like Cbl FAT-family cadherin CBL N-terminus CBL receptors SH3 AT-hook domain C-myb Mg-chelatase catalyses insertion EF hand-like Cbl FAT-family cadherin Mg-Proto Mg-chelatase FMR2 nuclear proteins GUN4 (hetero- and homo-) 3 structural Cbl_N2 CLPQ motif Ca2+-mediated cell-cell FMR2 nuclear proteins GUN4 (Proto-oncogene AF4) (b-HLH-lz) Max Cmyb_C Cyanobacterium AF-4 proto-oncoprotein AF4 protein Mg-Proto Mg-chelatase C-terminal CA Cadherin FMR2 nuclear proteins GUN47th position alpha helix AAA VWA C-terminus Cmyb_C Cyanobacterium CLPQ motif Ca2+-mediated cell-cell DNA binding Myc-Max Drosophila GUN4 plastid GUN4-like Arabidopsis Helianthus annuus Magnesium chelatase Mg-Proto Mg-chelatase FMR2 nuclear proteins GUN4 FMR2 nuclear proteins GUN4 CLPQ motif Ca2+-mediated cell-cell Cmyb_C Cyanobacterium (Proto-oncogene AF4) (b-HLH-lz) Max7th position alpha helix AAA VWA C-terminus (hetero- and homo-) 3 structural Cbl_N2 Mg-Proto Mg-chelatase (Proto-oncogene AF4) (b-HLH-lz) Max GUN4 plastid GUN4-like Arabidopsis AF-4 proto-oncoprotein AF4 protein Mg-Proto Mg-chelatase Cmyb_C Cyanobacterium AF-4 proto-oncoprotein AF4 protein (hetero- and homo-) 3 structural Cbl_N2 (hetero- and homo-) 3 structural Cbl_N2 C-terminal CA Cadherin CLPQ motif Ca2+-mediated cell-cell CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase CLPQ motif Ca2+-mediated cell-cell Mg-chelatase catalyses insertion FMR2 nuclear proteins GUN4 (hetero- and homo-) 3 structural Cbl_N2 C-terminal CA Cadherin

FMR2 nuclear proteins GUN4 CLPQ motif Ca2+-mediated cell-cell Cmyb_C Cyanobacterium AT-hook domain C-myb Mg-chelatase catalyses insertion Cmyb_C Cyanobacterium (hetero- and homo-) 3 structural Cbl_N2 GUN4 plastid GUN4-like Arabidopsis EF hand-like Cbl FAT-family cadherin FMR2 nuclear proteins GUN4 FMR2 nuclear proteins GUN4 CLPQ motif Ca2+-mediated cell-cell (hetero- and homo-) 3 structural Cbl_N2 FMR2 nuclear proteins GUN4 Helianthus annuus Magnesium chelatase Mg-chelatase catalyses insertion FMR2 nuclear proteins GUN4 CLPQ motif Ca2+-mediated cell-cell CLPQ motif Ca2+-mediated cell-cell C-terminal CA Cadherin AT-hook domain C-myb FMR2 nuclear proteins GUN4 DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase Mg-chelatase catalyses insertion C-terminal CA Cadherin AF-4 proto-oncoprotein AF4 protein C-terminal CA Cadherin EF hand-like Cbl FAT-family cadherin FMR2 nuclear proteins GUN4 (Proto-oncogene AF4) (b-HLH-lz) Max EF hand-like Cbl FAT-family cadherin CLPQ motif Ca2+-mediated cell-cell Cmyb_C Cyanobacterium AF-4 proto-oncoprotein AF4 protein Cmyb_C Cyanobacterium EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb C-terminal CA Cadherin FMR2 nuclear proteins GUN4 FMR2 nuclear proteins GUN4 C-terminal CA Cadherin AT-hook domain C-myb AT-hook domain C-myb AT-hook domain C-myb C-terminal CA Cadherin AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis7th position alpha helix AAA VWA C-terminus CBL N-terminus CBL receptors SH3 C-terminal CA Cadherin Mg-chelatase catalyses insertion GUN4 plastid GUN4-like Arabidopsis DNA binding Myc-Max Drosophila (Proto-oncogene AF4) (b-HLH-lz) Max C-terminal CA Cadherin GUN4 plastid GUN4-like Arabidopsis AF-4 proto-oncoprotein AF4 protein (Proto-oncogene AF4) (b-HLH-lz) Max DNA binding Myc-Max Drosophila Mg-chelatase catalyses insertion (Proto-oncogene AF4) (b-HLH-lz) Max Mg-Proto Mg-chelatase GUN4 plastid GUN4-like Arabidopsis

CBL N-terminus CBL receptors SH3 Cmyb_C Cyanobacterium CLPQ motif Ca2+-mediated cell-cell CBL N-terminus CBL receptors SH3 AF-4 proto-oncoprotein AF4 protein7th position alpha helix AAA VWA C-terminus (Proto-oncogene AF4) (b-HLH-lz) Max7th position alpha helix AAA VWA C-terminus Helianthus annuus Magnesium chelatase Mg-chelatase catalyses insertion GUN4 plastid GUN4-like Arabidopsis GUN4 plastid GUN4-like Arabidopsis EF hand-like Cbl FAT-family cadherin GUN4 plastid GUN4-like Arabidopsis Helianthus annuus Magnesium chelatase Mg-Proto Mg-chelatase (Proto-oncogene AF4) (b-HLH-lz) Max Helianthus annuus Magnesium chelatase CBL N-terminus CBL receptors SH3 CLPQ motif Ca2+-mediated cell-cell EF hand-like Cbl FAT-family cadherin AF-4 proto-oncoprotein AF4 protein GUN4 plastid GUN4-like Arabidopsis GUN4 plastid GUN4-like Arabidopsis Mg-chelatase catalyses insertion EF hand-like Cbl FAT-family cadherin CLPQ motif Ca2+-mediated cell-cell FMR2 nuclear proteins GUN4 (hetero- and homo-) 3 structural Cbl_N2 C-terminal CA Cadherin AT-hook domain C-myb CLPQ motif Ca2+-mediated cell-cell Cmyb_C Cyanobacterium EF hand-like Cbl FAT-family cadherin CBL N-terminus CBL receptors SH3 FMR2 nuclear proteins GUN4 GUN4 plastid GUN4-like Arabidopsis Mg-Proto Mg-chelatase FMR2 nuclear proteins GUN4 EF hand-like Cbl FAT-family cadherin (Proto-oncogene AF4) (b-HLH-lz) Max GUN4 plastid GUN4-like Arabidopsis (hetero- and homo-) 3 structural Cbl_N2 Cmyb_C Cyanobacterium DNA binding Myc-Max Drosophila C-terminal CA Cadherin Mg-chelatase catalyses insertion (Proto-oncogene AF4) (b-HLH-lz) Max C-terminal CA Cadherin EF hand-like Cbl FAT-family cadherin AF-4 proto-oncoprotein AF4 protein GUN4 plastid GUN4-like Arabidopsis7th position alpha helix AAA VWA C-terminus CLPQ motif Ca2+-mediated cell-cell (hetero- and homo-) 3 structural Cbl_N2 (hetero- and homo-) 3 structural Cbl_N2 FMR2 nuclear proteins GUN47th position alpha helix AAA VWA C-terminus Mg-Proto Mg-chelatase Mg-Proto Mg-chelatase Cmyb_C Cyanobacterium EF hand-like Cbl FAT-family cadherin CLPQ motif Ca2+-mediated cell-cell AF-4 proto-oncoprotein AF4 protein

FMR2 nuclear proteins GUN4 CBL N-terminus CBL receptors SH3 (hetero- and homo-) 3 structural Cbl_N2 AF-4 proto-oncoprotein AF4 protein AT-hook domain C-myb Mg-Proto Mg-chelatase (Proto-oncogene AF4) (b-HLH-lz) Max Cmyb_C Cyanobacterium C-terminal CA Cadherin EF hand-like Cbl FAT-family cadherin Cmyb_C Cyanobacterium Cmyb_C Cyanobacterium DNA binding Myc-Max Drosophila (Proto-oncogene AF4) (b-HLH-lz) Max DNA binding Myc-Max Drosophila C-terminal CA Cadherin CBL N-terminus CBL receptors SH3 (hetero- and homo-) 3 structural Cbl_N2 CLPQ motif Ca2+-mediated cell-cell EF hand-like Cbl FAT-family cadherin CLPQ motif Ca2+-mediated cell-cell Cmyb_C Cyanobacterium EF hand-like Cbl FAT-family cadherin GUN4 plastid GUN4-like Arabidopsis CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase (Proto-oncogene AF4) (b-HLH-lz) Max FMR2 nuclear proteins GUN4 (Proto-oncogene AF4) (b-HLH-lz) Max EF hand-like Cbl FAT-family cadherin Mg-Proto Mg-chelatase AT-hook domain C-myb (Proto-oncogene AF4) (b-HLH-lz) Max CBL N-terminus CBL receptors SH3 C-terminal CA Cadherin AT-hook domain C-myb Mg-chelatase catalyses insertion EF hand-like Cbl FAT-family cadherin Helianthus annuus Magnesium chelatase GUN4 plastid GUN4-like Arabidopsis CLPQ motif Ca2+-mediated cell-cell Mg-Proto Mg-chelatase (hetero- and homo-) 3 structural Cbl_N2 GUN4 plastid GUN4-like Arabidopsis CLPQ motif Ca2+-mediated cell-cell EF hand-like Cbl FAT-family cadherin EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb (hetero- and homo-) 3 structural Cbl_N27th position alpha helix AAA VWA C-terminus FMR2 nuclear proteins GUN4 (hetero- and homo-) 3 structural Cbl_N2 (hetero- and homo-) 3 structural Cbl_N2 DNA binding Myc-Max Drosophila AT-hook domain C-myb Mg-chelatase catalyses insertion7th position alpha helix AAA VWA C-terminus CLPQ motif Ca2+-mediated cell-cell DNA binding Myc-Max Drosophila C-terminal CA Cadherin Mg-chelatase catalyses insertion EF hand-like Cbl FAT-family cadherin AF-4 proto-oncoprotein AF4 protein AT-hook domain C-myb

CBL N-terminus CBL receptors SH3 C-terminal CA Cadherin C-terminal CA Cadherin AT-hook domain C-myb7th position alpha helix AAA VWA C-terminus Helianthus annuus Magnesium chelatase Mg-Proto Mg-chelatase Cmyb_C Cyanobacterium CBL N-terminus CBL receptors SH3 Cmyb_C Cyanobacterium EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb Helianthus annuus Magnesium chelatase7th position alpha helix AAA VWA C-terminus Helianthus annuus Magnesium chelatase AT-hook domain C-myb (Proto-oncogene AF4) (b-HLH-lz) Max Mg-chelatase catalyses insertion Helianthus annuus Magnesium chelatase AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis C-terminal CA Cadherin Cmyb_C Cyanobacterium7th position alpha helix AAA VWA C-terminus AF-4 proto-oncoprotein AF4 protein Helianthus annuus Magnesium chelatase Mg-Proto Mg-chelatase (Proto-oncogene AF4) (b-HLH-lz) Max (hetero- and homo-) 3 structural Cbl_N27th position alpha helix AAA VWA C-terminus CBL N-terminus CBL receptors SH3 Mg-Proto Mg-chelatase7th position alpha helix AAA VWA C-terminus (hetero- and homo-) 3 structural Cbl_N2 FMR2 nuclear proteins GUN4 GUN4 plastid GUN4-like Arabidopsis Mg-Proto Mg-chelatase AF-4 proto-oncoprotein AF4 protein AF-4 proto-oncoprotein AF4 protein (Proto-oncogene AF4) (b-HLH-lz) Max GUN4 plastid GUN4-like Arabidopsis7th position alpha helix AAA VWA C-terminus Helianthus annuus Magnesium chelatase CLPQ motif Ca2+-mediated cell-cell Mg-chelatase catalyses insertion AT-hook domain C-myb DNA binding Myc-Max Drosophila CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase AF-4 proto-oncoprotein AF4 protein Helianthus annuus Magnesium chelatase7th position alpha helix AAA VWA C-terminus FMR2 nuclear proteins GUN4 CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase (hetero- and homo-) 3 structural Cbl_N2 Mg-Proto Mg-chelatase C-terminal CA Cadherin Mg-Proto Mg-chelatase Helianthus annuus Magnesium chelatase C-terminal CA Cadherin (Proto-oncogene AF4) (b-HLH-lz) Max DNA binding Myc-Max Drosophila AT-hook domain C-myb

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C-terminal CA Cadherin CBL N-terminus CBL receptors SH3 AT-hook domain C-myb Mg-chelatase catalyses insertion FMR2 nuclear proteins GUN4 AT-hook domain C-myb Mg-chelatase catalyses insertion GUN4 plastid GUN4-like Arabidopsis CLPQ motif Ca2+-mediated cell-cell CBL N-terminus CBL receptors SH3 Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N2 Cmyb_C Cyanobacterium CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase AF-4 proto-oncoprotein AF4 protein Mg-chelatase catalyses insertion AT-hook domain C-myb Cmyb_C Cyanobacterium7th position alpha helix AAA VWA C-terminus Mg-Proto Mg-chelatase (Proto-oncogene AF4) (b-HLH-lz) Max CBL N-terminus CBL receptors SH3 CBL N-terminus CBL receptors SH3 AT-hook domain C-myb CLPQ motif Ca2+-mediated cell-cell CBL N-terminus CBL receptors SH3 EF hand-like Cbl FAT-family cadherin GUN4 plastid GUN4-like Arabidopsis EF hand-like Cbl FAT-family cadherin AF-4 proto-oncoprotein AF4 protein FMR2 nuclear proteins GUN4 C-terminal CA Cadherin AT-hook domain C-myb (hetero- and homo-) 3 structural Cbl_N2 FMR2 nuclear proteins GUN4 FMR2 nuclear proteins GUN4 (hetero- and homo-) 3 structural Cbl_N2 Mg-Proto Mg-chelatase Mg-chelatase catalyses insertion Cmyb_C Cyanobacterium FMR2 nuclear proteins GUN4 GUN4 plastid GUN4-like Arabidopsis EF hand-like Cbl FAT-family cadherin C-terminal CA Cadherin AF-4 proto-oncoprotein AF4 protein CBL N-terminus CBL receptors SH3 FMR2 nuclear proteins GUN4 FMR2 nuclear proteins GUN4 CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase FMR2 nuclear proteins GUN4 EF hand-like Cbl FAT-family cadherin CBL N-terminus CBL receptors SH3 (hetero- and homo-) 3 structural Cbl_N27th position alpha helix AAA VWA C-terminus Cmyb_C Cyanobacterium C-terminal CA Cadherin Mg-Proto Mg-chelatase Cmyb_C Cyanobacterium Helianthus annuus Magnesium chelatase (hetero- and homo-) 3 structural Cbl_N2 EF hand-like Cbl FAT-family cadherin Mg-chelatase catalyses insertion

7th position alpha helix AAA VWA C-terminus CLPQ motif Ca2+-mediated cell-cell Cmyb_C Cyanobacterium AT-hook domain C-myb AT-hook domain C-myb AF-4 proto-oncoprotein AF4 protein AT-hook domain C-myb7th position alpha helix AAA VWA C-terminus CBL N-terminus CBL receptors SH3 CBL N-terminus CBL receptors SH3 GUN4 plastid GUN4-like Arabidopsis (Proto-oncogene AF4) (b-HLH-lz) Max AT-hook domain C-myb DNA binding Myc-Max Drosophila Mg-chelatase catalyses insertion EF hand-like Cbl FAT-family cadherin FMR2 nuclear proteins GUN4 C-terminal CA Cadherin Mg-Proto Mg-chelatase C-terminal CA Cadherin C-terminal CA Cadherin Helianthus annuus Magnesium chelatase FMR2 nuclear proteins GUN4 CBL N-terminus CBL receptors SH37th position alpha helix AAA VWA C-terminus Mg-chelatase catalyses insertion C-terminal CA Cadherin Mg-chelatase catalyses insertion AT-hook domain C-myb C-terminal CA Cadherin Mg-chelatase catalyses insertion EF hand-like Cbl FAT-family cadherin (hetero- and homo-) 3 structural Cbl_N2 Helianthus annuus Magnesium chelatase FMR2 nuclear proteins GUN4 AF-4 proto-oncoprotein AF4 protein AT-hook domain C-myb AT-hook domain C-myb CLPQ motif Ca2+-mediated cell-cell AF-4 proto-oncoprotein AF4 protein Mg-chelatase catalyses insertion7th position alpha helix AAA VWA C-terminus Cmyb_C Cyanobacterium C-terminal CA Cadherin7th position alpha helix AAA VWA C-terminus GUN4 plastid GUN4-like Arabidopsis Helianthus annuus Magnesium chelatase Mg-Proto Mg-chelatase Mg-Proto Mg-chelatase CLPQ motif Ca2+-mediated cell-cell Mg-Proto Mg-chelatase AF-4 proto-oncoprotein AF4 protein AF-4 proto-oncoprotein AF4 protein CLPQ motif Ca2+-mediated cell-cell Cmyb_C Cyanobacterium7th position alpha helix AAA VWA C-terminus CLPQ motif Ca2+-mediated cell-cell C-terminal CA Cadherin CLPQ motif Ca2+-mediated cell-cell AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis Mg-Proto Mg-chelatase CLPQ motif Ca2+-mediated cell-cell Cmyb_C Cyanobacterium

C-terminal CA Cadherin AT-hook domain C-myb CBL N-terminus CBL receptors SH3 C-terminal CA Cadherin AT-hook domain C-myb Cmyb_C Cyanobacterium FMR2 nuclear proteins GUN4 (hetero- and homo-) 3 structural Cbl_N2 Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N2 AF-4 proto-oncoprotein AF4 protein Helianthus annuus Magnesium chelatase DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase CLPQ motif Ca2+-mediated cell-cell EF hand-like Cbl FAT-family cadherin C-terminal CA Cadherin CLPQ motif Ca2+-mediated cell-cell (Proto-oncogene AF4) (b-HLH-lz) Max (Proto-oncogene AF4) (b-HLH-lz) Max CBL N-terminus CBL receptors SH3 AF-4 proto-oncoprotein AF4 protein EF hand-like Cbl FAT-family cadherin GUN4 plastid GUN4-like Arabidopsis Helianthus annuus Magnesium chelatase DNA binding Myc-Max Drosophila FMR2 nuclear proteins GUN4 AT-hook domain C-myb EF hand-like Cbl FAT-family cadherin DNA binding Myc-Max Drosophila C-terminal CA Cadherin AF-4 proto-oncoprotein AF4 protein CBL N-terminus CBL receptors SH37th position alpha helix AAA VWA C-terminus C-terminal CA Cadherin EF hand-like Cbl FAT-family cadherin Mg-Proto Mg-chelatase CBL N-terminus CBL receptors SH3 CLPQ motif Ca2+-mediated cell-cell DNA binding Myc-Max Drosophila (Proto-oncogene AF4) (b-HLH-lz) Max AT-hook domain C-myb DNA binding Myc-Max Drosophila CLPQ motif Ca2+-mediated cell-cell CBL N-terminus CBL receptors SH3 Mg-Proto Mg-chelatase (Proto-oncogene AF4) (b-HLH-lz) Max Cmyb_C Cyanobacterium Helianthus annuus Magnesium chelatase7th position alpha helix AAA VWA C-terminus AT-hook domain C-myb Cmyb_C Cyanobacterium (Proto-oncogene AF4) (b-HLH-lz) Max EF hand-like Cbl FAT-family cadherin Helianthus annuus Magnesium chelatase DNA binding Myc-Max Drosophila Cmyb_C Cyanobacterium Mg-Proto Mg-chelatase Mg-chelatase catalyses insertion (Proto-oncogene AF4) (b-HLH-lz) Max Helianthus annuus Magnesium chelatase (hetero- and homo-) 3 structural Cbl_N2 C-terminal CA Cadherin EF hand-like Cbl FAT-family cadherin

Mg-Proto Mg-chelatase Helianthus annuus Magnesium chelatase CBL N-terminus CBL receptors SH3 CLPQ motif Ca2+-mediated cell-cell7th position alpha helix AAA VWA C-terminus AT-hook domain C-myb Mg-chelatase catalyses insertion Cmyb_C Cyanobacterium7th position alpha helix AAA VWA C-terminus C-terminal CA Cadherin Mg-Proto Mg-chelatase FMR2 nuclear proteins GUN4 Mg-Proto Mg-chelatase Mg-chelatase catalyses insertion Mg-Proto Mg-chelatase CBL N-terminus CBL receptors SH3 GUN4 plastid GUN4-like Arabidopsis Mg-Proto Mg-chelatase Helianthus annuus Magnesium chelatase7th position alpha helix AAA VWA C-terminus (hetero- and homo-) 3 structural Cbl_N2 AF-4 proto-oncoprotein AF4 protein FMR2 nuclear proteins GUN4 DNA binding Myc-Max Drosophila DNA binding Myc-Max Drosophila (hetero- and homo-) 3 structural Cbl_N2 Helianthus annuus Magnesium chelatase CLPQ motif Ca2+-mediated cell-cell Cmyb_C Cyanobacterium C-terminal CA Cadherin CLPQ motif Ca2+-mediated cell-cell EF hand-like Cbl FAT-family cadherin DNA binding Myc-Max Drosophila GUN4 plastid GUN4-like Arabidopsis AT-hook domain C-myb (hetero- and homo-) 3 structural Cbl_N2 AF-4 proto-oncoprotein AF4 protein (hetero- and homo-) 3 structural Cbl_N2 AT-hook domain C-myb EF hand-like Cbl FAT-family cadherin (Proto-oncogene AF4) (b-HLH-lz) Max C-terminal CA Cadherin Helianthus annuus Magnesium chelatase GUN4 plastid GUN4-like Arabidopsis Mg-chelatase catalyses insertion Mg-chelatase catalyses insertion GUN4 plastid GUN4-like Arabidopsis DNA binding Myc-Max Drosophila Mg-chelatase catalyses insertion CLPQ motif Ca2+-mediated cell-cell C-terminal CA Cadherin AT-hook domain C-myb Mg-Proto Mg-chelatase CBL N-terminus CBL receptors SH3 Mg-chelatase catalyses insertion FMR2 nuclear proteins GUN4 EF hand-like Cbl FAT-family cadherin7th position alpha helix AAA VWA C-terminus AF-4 proto-oncoprotein AF4 protein CLPQ motif Ca2+-mediated cell-cell CLPQ motif Ca2+-mediated cell-cell CLPQ motif Ca2+-mediated cell-cell Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N2

(hetero- and homo-) 3 structural Cbl_N27th position alpha helix AAA VWA C-terminus AT-hook domain C-myb CLPQ motif Ca2+-mediated cell-cell FMR2 nuclear proteins GUN4 FMR2 nuclear proteins GUN4 (Proto-oncogene AF4) (b-HLH-lz) Max AT-hook domain C-myb (Proto-oncogene AF4) (b-HLH-lz) Max FMR2 nuclear proteins GUN4 Helianthus annuus Magnesium chelatase Mg-chelatase catalyses insertion AT-hook domain C-myb CLPQ motif Ca2+-mediated cell-cell AF-4 proto-oncoprotein AF4 protein FMR2 nuclear proteins GUN4 Mg-chelatase catalyses insertion AF-4 proto-oncoprotein AF4 protein CLPQ motif Ca2+-mediated cell-cell C-terminal CA Cadherin Cmyb_C Cyanobacterium CLPQ motif Ca2+-mediated cell-cell CLPQ motif Ca2+-mediated cell-cell CLPQ motif Ca2+-mediated cell-cell DNA binding Myc-Max Drosophila7th position alpha helix AAA VWA C-terminus FMR2 nuclear proteins GUN4 AT-hook domain C-myb Helianthus annuus Magnesium chelatase Cmyb_C Cyanobacterium EF hand-like Cbl FAT-family cadherin7th position alpha helix AAA VWA C-terminus FMR2 nuclear proteins GUN4 (Proto-oncogene AF4) (b-HLH-lz) Max EF hand-like Cbl FAT-family cadherin7th position alpha helix AAA VWA C-terminus7th position alpha helix AAA VWA C-terminus (Proto-oncogene AF4) (b-HLH-lz) Max7th position alpha helix AAA VWA C-terminus Cmyb_C Cyanobacterium Mg-Proto Mg-chelatase CLPQ motif Ca2+-mediated cell-cell EF hand-like Cbl FAT-family cadherin CBL N-terminus CBL receptors SH3 C-terminal CA Cadherin C-terminal CA Cadherin AF-4 proto-oncoprotein AF4 protein DNA binding Myc-Max Drosophila EF hand-like Cbl FAT-family cadherin Cmyb_C Cyanobacterium AT-hook domain C-myb C-terminal CA Cadherin (hetero- and homo-) 3 structural Cbl_N2 (Proto-oncogene AF4) (b-HLH-lz) Max C-terminal CA Cadherin AT-hook domain C-myb (Proto-oncogene AF4) (b-HLH-lz) Max CLPQ motif Ca2+-mediated cell-cell CLPQ motif Ca2+-mediated cell-cell AF-4 proto-oncoprotein AF4 protein C-terminal CA Cadherin GUN4 plastid GUN4-like Arabidopsis DNA binding Myc-Max Drosophila CBL N-terminus CBL receptors SH3

(Proto-oncogene AF4) (b-HLH-lz) Max CLPQ motif Ca2+-mediated cell-cell Mg-Proto Mg-chelatase Helianthus annuus Magnesium chelatase (hetero- and homo-) 3 structural Cbl_N2 AF-4 proto-oncoprotein AF4 protein FMR2 nuclear proteins GUN4 FMR2 nuclear proteins GUN4 Mg-Proto Mg-chelatase (Proto-oncogene AF4) (b-HLH-lz) Max FMR2 nuclear proteins GUN4 Mg-chelatase catalyses insertion DNA binding Myc-Max Drosophila AF-4 proto-oncoprotein AF4 protein (hetero- and homo-) 3 structural Cbl_N2 Helianthus annuus Magnesium chelatase C-terminal CA Cadherin C-terminal CA Cadherin Helianthus annuus Magnesium chelatase AT-hook domain C-myb Helianthus annuus Magnesium chelatase CLPQ motif Ca2+-mediated cell-cell DNA binding Myc-Max Drosophila Mg-Proto Mg-chelatase AF-4 proto-oncoprotein AF4 protein Cmyb_C Cyanobacterium7th position alpha helix AAA VWA C-terminus CBL N-terminus CBL receptors SH3 FMR2 nuclear proteins GUN4 C-terminal CA Cadherin Mg-chelatase catalyses insertion CLPQ motif Ca2+-mediated cell-cell Helianthus annuus Magnesium chelatase Helianthus annuus Magnesium chelatase AF-4 proto-oncoprotein AF4 protein (hetero- and homo-) 3 structural Cbl_N2 Mg-chelatase catalyses insertion GUN4 plastid GUN4-like Arabidopsis Helianthus annuus Magnesium chelatase Helianthus annuus Magnesium chelatase AT-hook domain C-myb CBL N-terminus CBL receptors SH3 GUN4 plastid GUN4-like Arabidopsis GUN4 plastid GUN4-like Arabidopsis7th position alpha helix AAA VWA C-terminus DNA binding Myc-Max Drosophila (Proto-oncogene AF4) (b-HLH-lz) Max Cmyb_C Cyanobacterium AT-hook domain C-myb (Proto-oncogene AF4) (b-HLH-lz) Max FMR2 nuclear proteins GUN4 FMR2 nuclear proteins GUN4 Cmyb_C Cyanobacterium CBL N-terminus CBL receptors SH3 EF hand-like Cbl FAT-family cadherin7th position alpha helix AAA VWA C-terminus Cmyb_C Cyanobacterium AT-hook domain C-myb CLPQ motif Ca2+-mediated cell-cell FMR2 nuclear proteins GUN4 FMR2 nuclear proteins GUN4 DNA binding Myc-Max Drosophila Mg-chelatase catalyses insertion DNA binding Myc-Max Drosophila

AT-hook domain C-myb (Proto-oncogene AF4) (b-HLH-lz) Max C-terminal CA Cadherin GUN4 plastid GUN4-like Arabidopsis (hetero- and homo-) 3 structural Cbl_N2 DNA binding Myc-Max Drosophila C-terminal CA Cadherin AT-hook domain C-myb Helianthus annuus Magnesium chelatase FMR2 nuclear proteins GUN4 Helianthus annuus Magnesium chelatase CLPQ motif Ca2+-mediated cell-cell (hetero- and homo-) 3 structural Cbl_N2 EF hand-like Cbl FAT-family cadherin Mg-chelatase catalyses insertion CLPQ motif Ca2+-mediated cell-cell7th position alpha helix AAA VWA C-terminus FMR2 nuclear proteins GUN4 FMR2 nuclear proteins GUN4 EF hand-like Cbl FAT-family cadherin AF-4 proto-oncoprotein AF4 protein C-terminal CA Cadherin EF hand-like Cbl FAT-family cadherin Helianthus annuus Magnesium chelatase DNA binding Myc-Max Drosophila (Proto-oncogene AF4) (b-HLH-lz) Max EF hand-like Cbl FAT-family cadherin DNA binding Myc-Max Drosophila GUN4 plastid GUN4-like Arabidopsis CBL N-terminus CBL receptors SH3 (hetero- and homo-) 3 structural Cbl_N2 Mg-chelatase catalyses insertion DNA binding Myc-Max Drosophila FMR2 nuclear proteins GUN4 AT-hook domain C-myb Mg-chelatase catalyses insertion EF hand-like Cbl FAT-family cadherin DNA binding Myc-Max Drosophila DNA binding Myc-Max Drosophila GUN4 plastid GUN4-like Arabidopsis Cmyb_C Cyanobacterium AF-4 proto-oncoprotein AF4 protein (hetero- and homo-) 3 structural Cbl_N2 AF-4 proto-oncoprotein AF4 protein AF-4 proto-oncoprotein AF4 protein FMR2 nuclear proteins GUN4 (Proto-oncogene AF4) (b-HLH-lz) Max (hetero- and homo-) 3 structural Cbl_N2 GUN4 plastid GUN4-like Arabidopsis EF hand-like Cbl FAT-family cadherin Cmyb_C Cyanobacterium DNA binding Myc-Max Drosophila AF-4 proto-oncoprotein AF4 protein Helianthus annuus Magnesium chelatase AT-hook domain C-myb C-terminal CA Cadherin FMR2 nuclear proteins GUN4 CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase AF-4 proto-oncoprotein AF4 protein AF-4 proto-oncoprotein AF4 protein (Proto-oncogene AF4) (b-HLH-lz) Max Mg-chelatase catalyses insertion C-terminal CA Cadherin

AF-4 proto-oncoprotein AF4 protein AT-hook domain C-myb (hetero- and homo-) 3 structural Cbl_N2 (hetero- and homo-) 3 structural Cbl_N2 AF-4 proto-oncoprotein AF4 protein Cmyb_C Cyanobacterium7th position alpha helix AAA VWA C-terminus EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb AT-hook domain C-myb Mg-Proto Mg-chelatase GUN4 plastid GUN4-like Arabidopsis Cmyb_C Cyanobacterium CBL N-terminus CBL receptors SH3 (hetero- and homo-) 3 structural Cbl_N2 GUN4 plastid GUN4-like Arabidopsis CLPQ motif Ca2+-mediated cell-cell AT-hook domain C-myb EF hand-like Cbl FAT-family cadherin Mg-Proto Mg-chelatase Mg-Proto Mg-chelatase (hetero- and homo-) 3 structural Cbl_N2 Mg-chelatase catalyses insertion GUN4 plastid GUN4-like Arabidopsis CLPQ motif Ca2+-mediated cell-cell GUN4 plastid GUN4-like Arabidopsis EF hand-like Cbl FAT-family cadherin (Proto-oncogene AF4) (b-HLH-lz) Max EF hand-like Cbl FAT-family cadherin C-terminal CA Cadherin AF-4 proto-oncoprotein AF4 protein (hetero- and homo-) 3 structural Cbl_N2 CBL N-terminus CBL receptors SH3 Mg-Proto Mg-chelatase Helianthus annuus Magnesium chelatase EF hand-like Cbl FAT-family cadherin (Proto-oncogene AF4) (b-HLH-lz) Max DNA binding Myc-Max Drosophila CBL N-terminus CBL receptors SH37th position alpha helix AAA VWA C-terminus EF hand-like Cbl FAT-family cadherin C-terminal CA Cadherin CLPQ motif Ca2+-mediated cell-cell CBL N-terminus CBL receptors SH3 (hetero- and homo-) 3 structural Cbl_N27th position alpha helix AAA VWA C-terminus CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase CLPQ motif Ca2+-mediated cell-cell C-terminal CA Cadherin FMR2 nuclear proteins GUN4 Cmyb_C Cyanobacterium GUN4 plastid GUN4-like Arabidopsis (Proto-oncogene AF4) (b-HLH-lz) Max7th position alpha helix AAA VWA C-terminus (hetero- and homo-) 3 structural Cbl_N2 CLPQ motif Ca2+-mediated cell-cell AF-4 proto-oncoprotein AF4 protein7th position alpha helix AAA VWA C-terminus AT-hook domain C-myb CLPQ motif Ca2+-mediated cell-cell (Proto-oncogene AF4) (b-HLH-lz) Max Mg-chelatase catalyses insertion7th position alpha helix AAA VWA C-terminus

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DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis AT-hook domain C-myb Cmyb_C Cyanobacterium DNA binding Myc-Max Drosophila AF-4 proto-oncoprotein AF4 protein EF hand-like Cbl FAT-family cadherin GUN4 plastid GUN4-like Arabidopsis AT-hook domain C-myb C-terminal CA Cadherin Cmyb_C Cyanobacterium CLPQ motif Ca2+-mediated cell-cell Mg-chelatase catalyses insertion CLPQ motif Ca2+-mediated cell-cell C-terminal CA Cadherin GUN4 plastid GUN4-like Arabidopsis Mg-Proto Mg-chelatase EF hand-like Cbl FAT-family cadherin Helianthus annuus Magnesium chelatase Helianthus annuus Magnesium chelatase7th position alpha helix AAA VWA C-terminus Cmyb_C Cyanobacterium (Proto-oncogene AF4) (b-HLH-lz) Max C-terminal CA Cadherin DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase CLPQ motif Ca2+-mediated cell-cell Mg-chelatase catalyses insertion Helianthus annuus Magnesium chelatase C-terminal CA Cadherin Cmyb_C Cyanobacterium (Proto-oncogene AF4) (b-HLH-lz) Max Mg-Proto Mg-chelatase CBL N-terminus CBL receptors SH3 Mg-chelatase catalyses insertion CLPQ motif Ca2+-mediated cell-cell AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis (hetero- and homo-) 3 structural Cbl_N2 C-terminal CA Cadherin (hetero- and homo-) 3 structural Cbl_N27th position alpha helix AAA VWA C-terminus (hetero- and homo-) 3 structural Cbl_N2 (hetero- and homo-) 3 structural Cbl_N2 Mg-Proto Mg-chelatase CBL N-terminus CBL receptors SH3 C-terminal CA Cadherin (hetero- and homo-) 3 structural Cbl_N2 GUN4 plastid GUN4-like Arabidopsis GUN4 plastid GUN4-like Arabidopsis GUN4 plastid GUN4-like Arabidopsis Helianthus annuus Magnesium chelatase GUN4 plastid GUN4-like Arabidopsis Helianthus annuus Magnesium chelatase Mg-chelatase catalyses insertion AF-4 proto-oncoprotein AF4 protein (hetero- and homo-) 3 structural Cbl_N2 (hetero- and homo-) 3 structural Cbl_N2 AF-4 proto-oncoprotein AF4 protein Helianthus annuus Magnesium chelatase Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N2

Cmyb_C Cyanobacterium CLPQ motif Ca2+-mediated cell-cell AT-hook domain C-myb CBL N-terminus CBL receptors SH3 AT-hook domain C-myb Mg-chelatase catalyses insertion Helianthus annuus Magnesium chelatase Mg-chelatase catalyses insertion AT-hook domain C-myb Mg-chelatase catalyses insertion Helianthus annuus Magnesium chelatase Mg-Proto Mg-chelatase Helianthus annuus Magnesium chelatase Cmyb_C Cyanobacterium AT-hook domain C-myb C-terminal CA Cadherin Mg-Proto Mg-chelatase FMR2 nuclear proteins GUN4 GUN4 plastid GUN4-like Arabidopsis Mg-Proto Mg-chelatase C-terminal CA Cadherin Mg-chelatase catalyses insertion Mg-Proto Mg-chelatase (hetero- and homo-) 3 structural Cbl_N2 FMR2 nuclear proteins GUN47th position alpha helix AAA VWA C-terminus CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase CBL N-terminus CBL receptors SH3 C-terminal CA Cadherin CLPQ motif Ca2+-mediated cell-cell CBL N-terminus CBL receptors SH3 CBL N-terminus CBL receptors SH3 CBL N-terminus CBL receptors SH3 (hetero- and homo-) 3 structural Cbl_N2 Mg-chelatase catalyses insertion AF-4 proto-oncoprotein AF4 protein (Proto-oncogene AF4) (b-HLH-lz) Max CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase AT-hook domain C-myb FMR2 nuclear proteins GUN4 Mg-Proto Mg-chelatase FMR2 nuclear proteins GUN4 AT-hook domain C-myb Helianthus annuus Magnesium chelatase EF hand-like Cbl FAT-family cadherin GUN4 plastid GUN4-like Arabidopsis GUN4 plastid GUN4-like Arabidopsis FMR2 nuclear proteins GUN4 Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N2 EF hand-like Cbl FAT-family cadherin (Proto-oncogene AF4) (b-HLH-lz) Max Mg-Proto Mg-chelatase Cmyb_C Cyanobacterium FMR2 nuclear proteins GUN4 CLPQ motif Ca2+-mediated cell-cell AT-hook domain C-myb AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis DNA binding Myc-Max Drosophila Mg-Proto Mg-chelatase Cmyb_C Cyanobacterium

(Proto-oncogene AF4) (b-HLH-lz) Max CLPQ motif Ca2+-mediated cell-cell GUN4 plastid GUN4-like Arabidopsis EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb Cmyb_C Cyanobacterium (hetero- and homo-) 3 structural Cbl_N2 GUN4 plastid GUN4-like Arabidopsis DNA binding Myc-Max Drosophila EF hand-like Cbl FAT-family cadherin FMR2 nuclear proteins GUN4 AF-4 proto-oncoprotein AF4 protein FMR2 nuclear proteins GUN4 DNA binding Myc-Max Drosophila FMR2 nuclear proteins GUN4 AF-4 proto-oncoprotein AF4 protein FMR2 nuclear proteins GUN4 Mg-chelatase catalyses insertion AT-hook domain C-myb Mg-chelatase catalyses insertion7th position alpha helix AAA VWA C-terminus FMR2 nuclear proteins GUN47th position alpha helix AAA VWA C-terminus7th position alpha helix AAA VWA C-terminus AT-hook domain C-myb CBL N-terminus CBL receptors SH3 CLPQ motif Ca2+-mediated cell-cell (hetero- and homo-) 3 structural Cbl_N2 (Proto-oncogene AF4) (b-HLH-lz) Max7th position alpha helix AAA VWA C-terminus AT-hook domain C-myb FMR2 nuclear proteins GUN4 AF-4 proto-oncoprotein AF4 protein DNA binding Myc-Max Drosophila GUN4 plastid GUN4-like Arabidopsis7th position alpha helix AAA VWA C-terminus AT-hook domain C-myb EF hand-like Cbl FAT-family cadherin CLPQ motif Ca2+-mediated cell-cell FMR2 nuclear proteins GUN4 AF-4 proto-oncoprotein AF4 protein EF hand-like Cbl FAT-family cadherin EF hand-like Cbl FAT-family cadherin7th position alpha helix AAA VWA C-terminus7th position alpha helix AAA VWA C-terminus FMR2 nuclear proteins GUN4 AF-4 proto-oncoprotein AF4 protein7th position alpha helix AAA VWA C-terminus EF hand-like Cbl FAT-family cadherin (Proto-oncogene AF4) (b-HLH-lz) Max DNA binding Myc-Max Drosophila (Proto-oncogene AF4) (b-HLH-lz) Max (hetero- and homo-) 3 structural Cbl_N2 Cmyb_C Cyanobacterium C-terminal CA Cadherin Mg-Proto Mg-chelatase AF-4 proto-oncoprotein AF4 protein EF hand-like Cbl FAT-family cadherin Cmyb_C Cyanobacterium FMR2 nuclear proteins GUN4 Mg-Proto Mg-chelatase Cmyb_C Cyanobacterium CLPQ motif Ca2+-mediated cell-cell (Proto-oncogene AF4) (b-HLH-lz) Max

7th position alpha helix AAA VWA C-terminus DNA binding Myc-Max Drosophila DNA binding Myc-Max Drosophila CBL N-terminus CBL receptors SH3 AT-hook domain C-myb Mg-chelatase catalyses insertion DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase CLPQ motif Ca2+-mediated cell-cell GUN4 plastid GUN4-like Arabidopsis (hetero- and homo-) 3 structural Cbl_N2 C-terminal CA Cadherin GUN4 plastid GUN4-like Arabidopsis7th position alpha helix AAA VWA C-terminus Cmyb_C Cyanobacterium GUN4 plastid GUN4-like Arabidopsis AT-hook domain C-myb Mg-chelatase catalyses insertion EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb CBL N-terminus CBL receptors SH3 AT-hook domain C-myb CLPQ motif Ca2+-mediated cell-cell Helianthus annuus Magnesium chelatase EF hand-like Cbl FAT-family cadherin EF hand-like Cbl FAT-family cadherin CBL N-terminus CBL receptors SH3 GUN4 plastid GUN4-like Arabidopsis AF-4 proto-oncoprotein AF4 protein Helianthus annuus Magnesium chelatase7th position alpha helix AAA VWA C-terminus7th position alpha helix AAA VWA C-terminus Helianthus annuus Magnesium chelatase C-terminal CA Cadherin Mg-Proto Mg-chelatase DNA binding Myc-Max Drosophila Cmyb_C Cyanobacterium FMR2 nuclear proteins GUN4 AF-4 proto-oncoprotein AF4 protein Cmyb_C Cyanobacterium C-terminal CA Cadherin Mg-chelatase catalyses insertion Mg-chelatase catalyses insertion Cmyb_C Cyanobacterium FMR2 nuclear proteins GUN4 Mg-Proto Mg-chelatase AF-4 proto-oncoprotein AF4 protein AT-hook domain C-myb (hetero- and homo-) 3 structural Cbl_N2 AT-hook domain C-myb Helianthus annuus Magnesium chelatase Cmyb_C Cyanobacterium7th position alpha helix AAA VWA C-terminus AF-4 proto-oncoprotein AF4 protein (hetero- and homo-) 3 structural Cbl_N2 Mg-Proto Mg-chelatase Helianthus annuus Magnesium chelatase DNA binding Myc-Max Drosophila (Proto-oncogene AF4) (b-HLH-lz) Max7th position alpha helix AAA VWA C-terminus EF hand-like Cbl FAT-family cadherin7th position alpha helix AAA VWA C-terminus Mg-Proto Mg-chelatase CBL N-terminus CBL receptors SH3

DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase (Proto-oncogene AF4) (b-HLH-lz) Max (hetero- and homo-) 3 structural Cbl_N2 (hetero- and homo-) 3 structural Cbl_N2 EF hand-like Cbl FAT-family cadherin (Proto-oncogene AF4) (b-HLH-lz) Max FMR2 nuclear proteins GUN4 FMR2 nuclear proteins GUN4 (hetero- and homo-) 3 structural Cbl_N2 FMR2 nuclear proteins GUN4 FMR2 nuclear proteins GUN4 Cmyb_C Cyanobacterium GUN4 plastid GUN4-like Arabidopsis7th position alpha helix AAA VWA C-terminus Helianthus annuus Magnesium chelatase CLPQ motif Ca2+-mediated cell-cell GUN4 plastid GUN4-like Arabidopsis AF-4 proto-oncoprotein AF4 protein FMR2 nuclear proteins GUN4 CLPQ motif Ca2+-mediated cell-cell Mg-Proto Mg-chelatase GUN4 plastid GUN4-like Arabidopsis C-terminal CA Cadherin DNA binding Myc-Max Drosophila FMR2 nuclear proteins GUN4 (hetero- and homo-) 3 structural Cbl_N27th position alpha helix AAA VWA C-terminus Mg-Proto Mg-chelatase C-terminal CA Cadherin DNA binding Myc-Max Drosophila (hetero- and homo-) 3 structural Cbl_N2 Cmyb_C Cyanobacterium Mg-chelatase catalyses insertion CBL N-terminus CBL receptors SH3 FMR2 nuclear proteins GUN4 (Proto-oncogene AF4) (b-HLH-lz) Max EF hand-like Cbl FAT-family cadherin7th position alpha helix AAA VWA C-terminus Mg-Proto Mg-chelatase CLPQ motif Ca2+-mediated cell-cell GUN4 plastid GUN4-like Arabidopsis Helianthus annuus Magnesium chelatase (Proto-oncogene AF4) (b-HLH-lz) Max AT-hook domain C-myb7th position alpha helix AAA VWA C-terminus GUN4 plastid GUN4-like Arabidopsis AT-hook domain C-myb7th position alpha helix AAA VWA C-terminus (hetero- and homo-) 3 structural Cbl_N27th position alpha helix AAA VWA C-terminus GUN4 plastid GUN4-like Arabidopsis Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N2 Cmyb_C Cyanobacterium DNA binding Myc-Max Drosophila EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb (hetero- and homo-) 3 structural Cbl_N2 GUN4 plastid GUN4-like Arabidopsis (Proto-oncogene AF4) (b-HLH-lz) Max CLPQ motif Ca2+-mediated cell-cell AF-4 proto-oncoprotein AF4 protein Helianthus annuus Magnesium chelatase

AF-4 proto-oncoprotein AF4 protein (hetero- and homo-) 3 structural Cbl_N2 FMR2 nuclear proteins GUN4 AT-hook domain C-myb Mg-Proto Mg-chelatase Cmyb_C Cyanobacterium7th position alpha helix AAA VWA C-terminus7th position alpha helix AAA VWA C-terminus C-terminal CA Cadherin C-terminal CA Cadherin CLPQ motif Ca2+-mediated cell-cell Helianthus annuus Magnesium chelatase EF hand-like Cbl FAT-family cadherin Cmyb_C Cyanobacterium Helianthus annuus Magnesium chelatase CBL N-terminus CBL receptors SH3 Cmyb_C Cyanobacterium AT-hook domain C-myb Cmyb_C Cyanobacterium Mg-Proto Mg-chelatase Mg-Proto Mg-chelatase Mg-Proto Mg-chelatase (Proto-oncogene AF4) (b-HLH-lz) Max AT-hook domain C-myb (Proto-oncogene AF4) (b-HLH-lz) Max CLPQ motif Ca2+-mediated cell-cell Mg-chelatase catalyses insertion AT-hook domain C-myb (hetero- and homo-) 3 structural Cbl_N2 AF-4 proto-oncoprotein AF4 protein EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb DNA binding Myc-Max Drosophila Mg-Proto Mg-chelatase AT-hook domain C-myb Cmyb_C Cyanobacterium7th position alpha helix AAA VWA C-terminus Cmyb_C Cyanobacterium DNA binding Myc-Max Drosophila EF hand-like Cbl FAT-family cadherin CBL N-terminus CBL receptors SH3 DNA binding Myc-Max Drosophila C-terminal CA Cadherin Cmyb_C Cyanobacterium C-terminal CA Cadherin Mg-Proto Mg-chelatase AT-hook domain C-myb EF hand-like Cbl FAT-family cadherin Helianthus annuus Magnesium chelatase FMR2 nuclear proteins GUN4 CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase C-terminal CA Cadherin EF hand-like Cbl FAT-family cadherin EF hand-like Cbl FAT-family cadherin EF hand-like Cbl FAT-family cadherin EF hand-like Cbl FAT-family cadherin GUN4 plastid GUN4-like Arabidopsis CLPQ motif Ca2+-mediated cell-cell (hetero- and homo-) 3 structural Cbl_N2 DNA binding Myc-Max Drosophila EF hand-like Cbl FAT-family cadherin Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N2

GUN4 plastid GUN4-like Arabidopsis GUN4 plastid GUN4-like Arabidopsis (hetero- and homo-) 3 structural Cbl_N2 (Proto-oncogene AF4) (b-HLH-lz) Max Mg-chelatase catalyses insertion EF hand-like Cbl FAT-family cadherin Helianthus annuus Magnesium chelatase AT-hook domain C-myb FMR2 nuclear proteins GUN4 FMR2 nuclear proteins GUN4 C-terminal CA Cadherin (hetero- and homo-) 3 structural Cbl_N2 Cmyb_C Cyanobacterium DNA binding Myc-Max Drosophila Mg-Proto Mg-chelatase C-terminal CA Cadherin Mg-Proto Mg-chelatase Mg-chelatase catalyses insertion Mg-chelatase catalyses insertion CLPQ motif Ca2+-mediated cell-cell DNA binding Myc-Max Drosophila FMR2 nuclear proteins GUN4 (hetero- and homo-) 3 structural Cbl_N2 EF hand-like Cbl FAT-family cadherin C-terminal CA Cadherin DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase Cmyb_C Cyanobacterium AF-4 proto-oncoprotein AF4 protein Mg-chelatase catalyses insertion DNA binding Myc-Max Drosophila Mg-chelatase catalyses insertion Mg-Proto Mg-chelatase (Proto-oncogene AF4) (b-HLH-lz) Max (hetero- and homo-) 3 structural Cbl_N2 CLPQ motif Ca2+-mediated cell-cell (hetero- and homo-) 3 structural Cbl_N2 AF-4 proto-oncoprotein AF4 protein CLPQ motif Ca2+-mediated cell-cell FMR2 nuclear proteins GUN4 EF hand-like Cbl FAT-family cadherin (hetero- and homo-) 3 structural Cbl_N2 CLPQ motif Ca2+-mediated cell-cell C-terminal CA Cadherin (hetero- and homo-) 3 structural Cbl_N2 CBL N-terminus CBL receptors SH3 C-terminal CA Cadherin CBL N-terminus CBL receptors SH3 AF-4 proto-oncoprotein AF4 protein CBL N-terminus CBL receptors SH3 C-terminal CA Cadherin AF-4 proto-oncoprotein AF4 protein Mg-chelatase catalyses insertion GUN4 plastid GUN4-like Arabidopsis CBL N-terminus CBL receptors SH3 DNA binding Myc-Max Drosophila FMR2 nuclear proteins GUN4 Mg-chelatase catalyses insertion AF-4 proto-oncoprotein AF4 protein GUN4 plastid GUN4-like Arabidopsis Mg-chelatase catalyses insertion7th position alpha helix AAA VWA C-terminus AF-4 proto-oncoprotein AF4 protein FMR2 nuclear proteins GUN4

CLPQ motif Ca2+-mediated cell-cell FMR2 nuclear proteins GUN4 DNA binding Myc-Max Drosophila Mg-Proto Mg-chelatase AT-hook domain C-myb (hetero- and homo-) 3 structural Cbl_N2 AF-4 proto-oncoprotein AF4 protein Mg-Proto Mg-chelatase Cmyb_C Cyanobacterium Helianthus annuus Magnesium chelatase Mg-Proto Mg-chelatase DNA binding Myc-Max Drosophila CLPQ motif Ca2+-mediated cell-cell EF hand-like Cbl FAT-family cadherin CBL N-terminus CBL receptors SH3 DNA binding Myc-Max Drosophila GUN4 plastid GUN4-like Arabidopsis7th position alpha helix AAA VWA C-terminus7th position alpha helix AAA VWA C-terminus Helianthus annuus Magnesium chelatase Mg-Proto Mg-chelatase DNA binding Myc-Max Drosophila C-terminal CA Cadherin Mg-Proto Mg-chelatase Cmyb_C Cyanobacterium CBL N-terminus CBL receptors SH3 CLPQ motif Ca2+-mediated cell-cell (hetero- and homo-) 3 structural Cbl_N2 GUN4 plastid GUN4-like Arabidopsis Helianthus annuus Magnesium chelatase (Proto-oncogene AF4) (b-HLH-lz) Max CLPQ motif Ca2+-mediated cell-cell GUN4 plastid GUN4-like Arabidopsis DNA binding Myc-Max Drosophila GUN4 plastid GUN4-like Arabidopsis C-terminal CA Cadherin (Proto-oncogene AF4) (b-HLH-lz) Max GUN4 plastid GUN4-like Arabidopsis (Proto-oncogene AF4) (b-HLH-lz) Max7th position alpha helix AAA VWA C-terminus FMR2 nuclear proteins GUN4 GUN4 plastid GUN4-like Arabidopsis CLPQ motif Ca2+-mediated cell-cell AT-hook domain C-myb C-terminal CA Cadherin AF-4 proto-oncoprotein AF4 protein7th position alpha helix AAA VWA C-terminus Cmyb_C Cyanobacterium7th position alpha helix AAA VWA C-terminus FMR2 nuclear proteins GUN4 AF-4 proto-oncoprotein AF4 protein CBL N-terminus CBL receptors SH3 AF-4 proto-oncoprotein AF4 protein Mg-Proto Mg-chelatase Mg-Proto Mg-chelatase DNA binding Myc-Max Drosophila (hetero- and homo-) 3 structural Cbl_N2 DNA binding Myc-Max Drosophila Mg-chelatase catalyses insertion CLPQ motif Ca2+-mediated cell-cell AT-hook domain C-myb Mg-Proto Mg-chelatase Mg-Proto Mg-chelatase CBL N-terminus CBL receptors SH3

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Mg-Proto Mg-chelatase CBL N-terminus CBL receptors SH3 CLPQ motif Ca2+-mediated cell-cell Helianthus annuus Magnesium chelatase EF hand-like Cbl FAT-family cadherin Cmyb_C Cyanobacterium DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis DNA binding Myc-Max Drosophila FMR2 nuclear proteins GUN4 (hetero- and homo-) 3 structural Cbl_N27th position alpha helix AAA VWA C-terminus DNA binding Myc-Max Drosophila DNA binding Myc-Max Drosophila AT-hook domain C-myb CBL N-terminus CBL receptors SH37th position alpha helix AAA VWA C-terminus (Proto-oncogene AF4) (b-HLH-lz) Max (hetero- and homo-) 3 structural Cbl_N2 (hetero- and homo-) 3 structural Cbl_N2 C-terminal CA Cadherin AF-4 proto-oncoprotein AF4 protein Mg-Proto Mg-chelatase Mg-chelatase catalyses insertion FMR2 nuclear proteins GUN47th position alpha helix AAA VWA C-terminus EF hand-like Cbl FAT-family cadherin AF-4 proto-oncoprotein AF4 protein Mg-Proto Mg-chelatase7th position alpha helix AAA VWA C-terminus FMR2 nuclear proteins GUN4 AF-4 proto-oncoprotein AF4 protein FMR2 nuclear proteins GUN4 EF hand-like Cbl FAT-family cadherin Helianthus annuus Magnesium chelatase Mg-Proto Mg-chelatase DNA binding Myc-Max Drosophila CBL N-terminus CBL receptors SH3 EF hand-like Cbl FAT-family cadherin CBL N-terminus CBL receptors SH3 C-terminal CA Cadherin (Proto-oncogene AF4) (b-HLH-lz) Max CLPQ motif Ca2+-mediated cell-cell CBL N-terminus CBL receptors SH3 Mg-Proto Mg-chelatase (Proto-oncogene AF4) (b-HLH-lz) Max (hetero- and homo-) 3 structural Cbl_N27th position alpha helix AAA VWA C-terminus EF hand-like Cbl FAT-family cadherin CLPQ motif Ca2+-mediated cell-cell (hetero- and homo-) 3 structural Cbl_N2 (Proto-oncogene AF4) (b-HLH-lz) Max CBL N-terminus CBL receptors SH3 Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N27th position alpha helix AAA VWA C-terminus FMR2 nuclear proteins GUN4 Mg-chelatase catalyses insertion Helianthus annuus Magnesium chelatase Mg-Proto Mg-chelatase AT-hook domain C-myb FMR2 nuclear proteins GUN4

CBL N-terminus CBL receptors SH3 FMR2 nuclear proteins GUN4 FMR2 nuclear proteins GUN4 Cmyb_C Cyanobacterium Mg-Proto Mg-chelatase CLPQ motif Ca2+-mediated cell-cell AT-hook domain C-myb (Proto-oncogene AF4) (b-HLH-lz) Max GUN4 plastid GUN4-like Arabidopsis Cmyb_C Cyanobacterium CLPQ motif Ca2+-mediated cell-cell GUN4 plastid GUN4-like Arabidopsis DNA binding Myc-Max Drosophila AF-4 proto-oncoprotein AF4 protein Cmyb_C Cyanobacterium Mg-chelatase catalyses insertion Cmyb_C Cyanobacterium C-terminal CA Cadherin Helianthus annuus Magnesium chelatase CBL N-terminus CBL receptors SH3 CLPQ motif Ca2+-mediated cell-cell FMR2 nuclear proteins GUN4 GUN4 plastid GUN4-like Arabidopsis EF hand-like Cbl FAT-family cadherin Cmyb_C Cyanobacterium EF hand-like Cbl FAT-family cadherin CLPQ motif Ca2+-mediated cell-cell CBL N-terminus CBL receptors SH3 CBL N-terminus CBL receptors SH3 GUN4 plastid GUN4-like Arabidopsis C-terminal CA Cadherin AT-hook domain C-myb Mg-chelatase catalyses insertion FMR2 nuclear proteins GUN4 Cmyb_C Cyanobacterium Cmyb_C Cyanobacterium Mg-Proto Mg-chelatase C-terminal CA Cadherin Mg-chelatase catalyses insertion Mg-chelatase catalyses insertion (Proto-oncogene AF4) (b-HLH-lz) Max Cmyb_C Cyanobacterium DNA binding Myc-Max Drosophila (hetero- and homo-) 3 structural Cbl_N2 DNA binding Myc-Max Drosophila Mg-chelatase catalyses insertion EF hand-like Cbl FAT-family cadherin EF hand-like Cbl FAT-family cadherin Mg-Proto Mg-chelatase EF hand-like Cbl FAT-family cadherin Cmyb_C Cyanobacterium7th position alpha helix AAA VWA C-terminus GUN4 plastid GUN4-like Arabidopsis AT-hook domain C-myb EF hand-like Cbl FAT-family cadherin Mg-chelatase catalyses insertion CBL N-terminus CBL receptors SH3 (Proto-oncogene AF4) (b-HLH-lz) Max AT-hook domain C-myb (Proto-oncogene AF4) (b-HLH-lz) Max DNA binding Myc-Max Drosophila AT-hook domain C-myb FMR2 nuclear proteins GUN4 CLPQ motif Ca2+-mediated cell-cell

CBL N-terminus CBL receptors SH3 EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb Helianthus annuus Magnesium chelatase7th position alpha helix AAA VWA C-terminus Mg-Proto Mg-chelatase EF hand-like Cbl FAT-family cadherin7th position alpha helix AAA VWA C-terminus (Proto-oncogene AF4) (b-HLH-lz) Max7th position alpha helix AAA VWA C-terminus DNA binding Myc-Max Drosophila FMR2 nuclear proteins GUN4 AT-hook domain C-myb (hetero- and homo-) 3 structural Cbl_N2 AF-4 proto-oncoprotein AF4 protein AF-4 proto-oncoprotein AF4 protein CLPQ motif Ca2+-mediated cell-cell FMR2 nuclear proteins GUN4 AF-4 proto-oncoprotein AF4 protein Mg-chelatase catalyses insertion C-terminal CA Cadherin Cmyb_C Cyanobacterium AF-4 proto-oncoprotein AF4 protein CLPQ motif Ca2+-mediated cell-cell (hetero- and homo-) 3 structural Cbl_N27th position alpha helix AAA VWA C-terminus AF-4 proto-oncoprotein AF4 protein Mg-chelatase catalyses insertion Mg-Proto Mg-chelatase Mg-Proto Mg-chelatase CLPQ motif Ca2+-mediated cell-cell DNA binding Myc-Max Drosophila EF hand-like Cbl FAT-family cadherin (Proto-oncogene AF4) (b-HLH-lz) Max DNA binding Myc-Max Drosophila Mg-chelatase catalyses insertion AT-hook domain C-myb C-terminal CA Cadherin AF-4 proto-oncoprotein AF4 protein C-terminal CA Cadherin FMR2 nuclear proteins GUN4 Helianthus annuus Magnesium chelatase AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis DNA binding Myc-Max Drosophila Mg-Proto Mg-chelatase DNA binding Myc-Max Drosophila CBL N-terminus CBL receptors SH3 FMR2 nuclear proteins GUN4 AF-4 proto-oncoprotein AF4 protein CBL N-terminus CBL receptors SH3 (Proto-oncogene AF4) (b-HLH-lz) Max EF hand-like Cbl FAT-family cadherin Mg-chelatase catalyses insertion Mg-Proto Mg-chelatase GUN4 plastid GUN4-like Arabidopsis (hetero- and homo-) 3 structural Cbl_N2 AT-hook domain C-myb CLPQ motif Ca2+-mediated cell-cell Cmyb_C Cyanobacterium Helianthus annuus Magnesium chelatase CBL N-terminus CBL receptors SH3 AT-hook domain C-myb (hetero- and homo-) 3 structural Cbl_N2

EF hand-like Cbl FAT-family cadherin (Proto-oncogene AF4) (b-HLH-lz) Max DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase7th position alpha helix AAA VWA C-terminus GUN4 plastid GUN4-like Arabidopsis (Proto-oncogene AF4) (b-HLH-lz) Max Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N2 (hetero- and homo-) 3 structural Cbl_N2 AF-4 proto-oncoprotein AF4 protein Cmyb_C Cyanobacterium FMR2 nuclear proteins GUN4 CBL N-terminus CBL receptors SH3 AT-hook domain C-myb Mg-Proto Mg-chelatase C-terminal CA Cadherin FMR2 nuclear proteins GUN4 GUN4 plastid GUN4-like Arabidopsis AT-hook domain C-myb EF hand-like Cbl FAT-family cadherin Helianthus annuus Magnesium chelatase CLPQ motif Ca2+-mediated cell-cell DNA binding Myc-Max Drosophila EF hand-like Cbl FAT-family cadherin C-terminal CA Cadherin Mg-Proto Mg-chelatase GUN4 plastid GUN4-like Arabidopsis EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb Mg-chelatase catalyses insertion AF-4 proto-oncoprotein AF4 protein (Proto-oncogene AF4) (b-HLH-lz) Max (hetero- and homo-) 3 structural Cbl_N2 FMR2 nuclear proteins GUN47th position alpha helix AAA VWA C-terminus7th position alpha helix AAA VWA C-terminus GUN4 plastid GUN4-like Arabidopsis (Proto-oncogene AF4) (b-HLH-lz) Max FMR2 nuclear proteins GUN4 CLPQ motif Ca2+-mediated cell-cell CBL N-terminus CBL receptors SH3 GUN4 plastid GUN4-like Arabidopsis Cmyb_C Cyanobacterium CBL N-terminus CBL receptors SH3 AF-4 proto-oncoprotein AF4 protein AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis AF-4 proto-oncoprotein AF4 protein CLPQ motif Ca2+-mediated cell-cell AF-4 proto-oncoprotein AF4 protein FMR2 nuclear proteins GUN4 DNA binding Myc-Max Drosophila (Proto-oncogene AF4) (b-HLH-lz) Max Mg-chelatase catalyses insertion AF-4 proto-oncoprotein AF4 protein GUN4 plastid GUN4-like Arabidopsis CBL N-terminus CBL receptors SH3 AT-hook domain C-myb C-terminal CA Cadherin (hetero- and homo-) 3 structural Cbl_N2 Mg-Proto Mg-chelatase AF-4 proto-oncoprotein AF4 protein Cmyb_C Cyanobacterium

CLPQ motif Ca2+-mediated cell-cell CLPQ motif Ca2+-mediated cell-cell (hetero- and homo-) 3 structural Cbl_N2 Mg-chelatase catalyses insertion GUN4 plastid GUN4-like Arabidopsis AT-hook domain C-myb GUN4 plastid GUN4-like Arabidopsis AT-hook domain C-myb EF hand-like Cbl FAT-family cadherin Mg-chelatase catalyses insertion CLPQ motif Ca2+-mediated cell-cell DNA binding Myc-Max Drosophila DNA binding Myc-Max Drosophila FMR2 nuclear proteins GUN4 Helianthus annuus Magnesium chelatase GUN4 plastid GUN4-like Arabidopsis Helianthus annuus Magnesium chelatase DNA binding Myc-Max Drosophila Mg-Proto Mg-chelatase Helianthus annuus Magnesium chelatase AT-hook domain C-myb EF hand-like Cbl FAT-family cadherin GUN4 plastid GUN4-like Arabidopsis CBL N-terminus CBL receptors SH3 DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase C-terminal CA Cadherin Cmyb_C Cyanobacterium AF-4 proto-oncoprotein AF4 protein AT-hook domain C-myb C-terminal CA Cadherin FMR2 nuclear proteins GUN4 C-terminal CA Cadherin DNA binding Myc-Max Drosophila FMR2 nuclear proteins GUN4 Helianthus annuus Magnesium chelatase FMR2 nuclear proteins GUN4 AF-4 proto-oncoprotein AF4 protein Mg-Proto Mg-chelatase DNA binding Myc-Max Drosophila Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N2 CLPQ motif Ca2+-mediated cell-cell (Proto-oncogene AF4) (b-HLH-lz) Max AT-hook domain C-myb AT-hook domain C-myb (hetero- and homo-) 3 structural Cbl_N2 GUN4 plastid GUN4-like Arabidopsis (hetero- and homo-) 3 structural Cbl_N2 DNA binding Myc-Max Drosophila GUN4 plastid GUN4-like Arabidopsis EF hand-like Cbl FAT-family cadherin C-terminal CA Cadherin EF hand-like Cbl FAT-family cadherin GUN4 plastid GUN4-like Arabidopsis GUN4 plastid GUN4-like Arabidopsis (Proto-oncogene AF4) (b-HLH-lz) Max C-terminal CA Cadherin CLPQ motif Ca2+-mediated cell-cell Mg-chelatase catalyses insertion AF-4 proto-oncoprotein AF4 protein GUN4 plastid GUN4-like Arabidopsis C-terminal CA Cadherin DNA binding Myc-Max Drosophila

(hetero- and homo-) 3 structural Cbl_N2 Mg-Proto Mg-chelatase Mg-chelatase catalyses insertion CBL N-terminus CBL receptors SH3 Mg-Proto Mg-chelatase CBL N-terminus CBL receptors SH3 FMR2 nuclear proteins GUN4 DNA binding Myc-Max Drosophila DNA binding Myc-Max Drosophila Cmyb_C Cyanobacterium Mg-chelatase catalyses insertion CLPQ motif Ca2+-mediated cell-cell AT-hook domain C-myb CLPQ motif Ca2+-mediated cell-cell (Proto-oncogene AF4) (b-HLH-lz) Max Cmyb_C Cyanobacterium Mg-chelatase catalyses insertion EF hand-like Cbl FAT-family cadherin CLPQ motif Ca2+-mediated cell-cell Mg-Proto Mg-chelatase Cmyb_C Cyanobacterium C-terminal CA Cadherin (hetero- and homo-) 3 structural Cbl_N2 (hetero- and homo-) 3 structural Cbl_N2 Mg-Proto Mg-chelatase Helianthus annuus Magnesium chelatase AF-4 proto-oncoprotein AF4 protein7th position alpha helix AAA VWA C-terminus Mg-chelatase catalyses insertion Mg-chelatase catalyses insertion GUN4 plastid GUN4-like Arabidopsis Mg-Proto Mg-chelatase Helianthus annuus Magnesium chelatase Cmyb_C Cyanobacterium CBL N-terminus CBL receptors SH3 (Proto-oncogene AF4) (b-HLH-lz) Max Cmyb_C Cyanobacterium (Proto-oncogene AF4) (b-HLH-lz) Max FMR2 nuclear proteins GUN4 Helianthus annuus Magnesium chelatase (Proto-oncogene AF4) (b-HLH-lz) Max AF-4 proto-oncoprotein AF4 protein GUN4 plastid GUN4-like Arabidopsis Mg-Proto Mg-chelatase Helianthus annuus Magnesium chelatase GUN4 plastid GUN4-like Arabidopsis C-terminal CA Cadherin Helianthus annuus Magnesium chelatase Cmyb_C Cyanobacterium AF-4 proto-oncoprotein AF4 protein7th position alpha helix AAA VWA C-terminus AT-hook domain C-myb CBL N-terminus CBL receptors SH3 C-terminal CA Cadherin C-terminal CA Cadherin CBL N-terminus CBL receptors SH3 FMR2 nuclear proteins GUN4 FMR2 nuclear proteins GUN4 AT-hook domain C-myb C-terminal CA Cadherin (hetero- and homo-) 3 structural Cbl_N2 (Proto-oncogene AF4) (b-HLH-lz) Max AF-4 proto-oncoprotein AF4 protein Cmyb_C Cyanobacterium

Mg-Proto Mg-chelatase FMR2 nuclear proteins GUN4 (Proto-oncogene AF4) (b-HLH-lz) Max CBL N-terminus CBL receptors SH3 Cmyb_C Cyanobacterium CBL N-terminus CBL receptors SH3 (hetero- and homo-) 3 structural Cbl_N2 (hetero- and homo-) 3 structural Cbl_N2 FMR2 nuclear proteins GUN4 C-terminal CA Cadherin C-terminal CA Cadherin Cmyb_C Cyanobacterium EF hand-like Cbl FAT-family cadherin Mg-chelatase catalyses insertion AF-4 proto-oncoprotein AF4 protein Cmyb_C Cyanobacterium Cmyb_C Cyanobacterium GUN4 plastid GUN4-like Arabidopsis CLPQ motif Ca2+-mediated cell-cell AF-4 proto-oncoprotein AF4 protein EF hand-like Cbl FAT-family cadherin Cmyb_C Cyanobacterium Mg-Proto Mg-chelatase C-terminal CA Cadherin GUN4 plastid GUN4-like Arabidopsis Mg-chelatase catalyses insertion DNA binding Myc-Max Drosophila Cmyb_C Cyanobacterium Mg-chelatase catalyses insertion EF hand-like Cbl FAT-family cadherin C-terminal CA Cadherin7th position alpha helix AAA VWA C-terminus C-terminal CA Cadherin AT-hook domain C-myb (hetero- and homo-) 3 structural Cbl_N2 Cmyb_C Cyanobacterium CBL N-terminus CBL receptors SH3 Cmyb_C Cyanobacterium Mg-Proto Mg-chelatase Cmyb_C Cyanobacterium (Proto-oncogene AF4) (b-HLH-lz) Max DNA binding Myc-Max Drosophila EF hand-like Cbl FAT-family cadherin CBL N-terminus CBL receptors SH3 AT-hook domain C-myb EF hand-like Cbl FAT-family cadherin DNA binding Myc-Max Drosophila AT-hook domain C-myb Mg-chelatase catalyses insertion CLPQ motif Ca2+-mediated cell-cell7th position alpha helix AAA VWA C-terminus EF hand-like Cbl FAT-family cadherin (Proto-oncogene AF4) (b-HLH-lz) Max CBL N-terminus CBL receptors SH3 Cmyb_C Cyanobacterium FMR2 nuclear proteins GUN4 CLPQ motif Ca2+-mediated cell-cell7th position alpha helix AAA VWA C-terminus EF hand-like Cbl FAT-family cadherin EF hand-like Cbl FAT-family cadherin AF-4 proto-oncoprotein AF4 protein CLPQ motif Ca2+-mediated cell-cell Mg-chelatase catalyses insertion EF hand-like Cbl FAT-family cadherin

FMR2 nuclear proteins GUN4 (hetero- and homo-) 3 structural Cbl_N2 Cmyb_C Cyanobacterium Mg-Proto Mg-chelatase Helianthus annuus Magnesium chelatase AT-hook domain C-myb Helianthus annuus Magnesium chelatase DNA binding Myc-Max Drosophila DNA binding Myc-Max Drosophila CBL N-terminus CBL receptors SH3 AF-4 proto-oncoprotein AF4 protein EF hand-like Cbl FAT-family cadherin CLPQ motif Ca2+-mediated cell-cell AF-4 proto-oncoprotein AF4 protein GUN4 plastid GUN4-like Arabidopsis Mg-chelatase catalyses insertion C-terminal CA Cadherin FMR2 nuclear proteins GUN4 AF-4 proto-oncoprotein AF4 protein CBL N-terminus CBL receptors SH3 FMR2 nuclear proteins GUN4 EF hand-like Cbl FAT-family cadherin Helianthus annuus Magnesium chelatase EF hand-like Cbl FAT-family cadherin7th position alpha helix AAA VWA C-terminus CBL N-terminus CBL receptors SH3 Helianthus annuus Magnesium chelatase (Proto-oncogene AF4) (b-HLH-lz) Max AT-hook domain C-myb (Proto-oncogene AF4) (b-HLH-lz) Max7th position alpha helix AAA VWA C-terminus CLPQ motif Ca2+-mediated cell-cell (hetero- and homo-) 3 structural Cbl_N2 C-terminal CA Cadherin AT-hook domain C-myb Cmyb_C Cyanobacterium Mg-Proto Mg-chelatase EF hand-like Cbl FAT-family cadherin (Proto-oncogene AF4) (b-HLH-lz) Max GUN4 plastid GUN4-like Arabidopsis Mg-chelatase catalyses insertion CBL N-terminus CBL receptors SH3 (Proto-oncogene AF4) (b-HLH-lz) Max CLPQ motif Ca2+-mediated cell-cell CBL N-terminus CBL receptors SH3 Cmyb_C Cyanobacterium C-terminal CA Cadherin AT-hook domain C-myb AT-hook domain C-myb (hetero- and homo-) 3 structural Cbl_N2 CBL N-terminus CBL receptors SH3 (Proto-oncogene AF4) (b-HLH-lz) Max DNA binding Myc-Max Drosophila CLPQ motif Ca2+-mediated cell-cell7th position alpha helix AAA VWA C-terminus GUN4 plastid GUN4-like Arabidopsis Mg-chelatase catalyses insertion FMR2 nuclear proteins GUN4 CLPQ motif Ca2+-mediated cell-cell AT-hook domain C-myb AT-hook domain C-myb (hetero- and homo-) 3 structural Cbl_N2 C-terminal CA Cadherin FMR2 nuclear proteins GUN4

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Helianthus annuus Magnesium chelatase GUN4 plastid GUN4-like Arabidopsis C-terminal CA Cadherin CBL N-terminus CBL receptors SH3 Mg-chelatase catalyses insertion GUN4 plastid GUN4-like Arabidopsis CBL N-terminus CBL receptors SH3 DNA binding Myc-Max Drosophila EF hand-like Cbl FAT-family cadherin FMR2 nuclear proteins GUN4 CBL N-terminus CBL receptors SH3 C-terminal CA Cadherin FMR2 nuclear proteins GUN4 AT-hook domain C-myb DNA binding Myc-Max Drosophila Mg-Proto Mg-chelatase Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N2 DNA binding Myc-Max Drosophila C-terminal CA Cadherin EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb CBL N-terminus CBL receptors SH3 GUN4 plastid GUN4-like Arabidopsis C-terminal CA Cadherin AT-hook domain C-myb Helianthus annuus Magnesium chelatase C-terminal CA Cadherin EF hand-like Cbl FAT-family cadherin FMR2 nuclear proteins GUN4 GUN4 plastid GUN4-like Arabidopsis C-terminal CA Cadherin Cmyb_C Cyanobacterium Mg-chelatase catalyses insertion (Proto-oncogene AF4) (b-HLH-lz) Max EF hand-like Cbl FAT-family cadherin Cmyb_C Cyanobacterium GUN4 plastid GUN4-like Arabidopsis C-terminal CA Cadherin (Proto-oncogene AF4) (b-HLH-lz) Max (hetero- and homo-) 3 structural Cbl_N2 GUN4 plastid GUN4-like Arabidopsis (hetero- and homo-) 3 structural Cbl_N2 CLPQ motif Ca2+-mediated cell-cell (hetero- and homo-) 3 structural Cbl_N27th position alpha helix AAA VWA C-terminus GUN4 plastid GUN4-like Arabidopsis Mg-chelatase catalyses insertion CLPQ motif Ca2+-mediated cell-cell DNA binding Myc-Max Drosophila DNA binding Myc-Max Drosophila EF hand-like Cbl FAT-family cadherin AT-hook domain C-myb7th position alpha helix AAA VWA C-terminus Mg-Proto Mg-chelatase (Proto-oncogene AF4) (b-HLH-lz) Max EF hand-like Cbl FAT-family cadherin Mg-Proto Mg-chelatase CBL N-terminus CBL receptors SH3 DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase C-terminal CA Cadherin Mg-Proto Mg-chelatase C-terminal CA Cadherin

CLPQ motif Ca2+-mediated cell-cell AT-hook domain C-myb FMR2 nuclear proteins GUN4 Helianthus annuus Magnesium chelatase (Proto-oncogene AF4) (b-HLH-lz) Max C-terminal CA Cadherin (hetero- and homo-) 3 structural Cbl_N2 AT-hook domain C-myb C-terminal CA Cadherin EF hand-like Cbl FAT-family cadherin C-terminal CA Cadherin (hetero- and homo-) 3 structural Cbl_N2 Cmyb_C Cyanobacterium CBL N-terminus CBL receptors SH3 (hetero- and homo-) 3 structural Cbl_N2 Mg-chelatase catalyses insertion (hetero- and homo-) 3 structural Cbl_N2 CLPQ motif Ca2+-mediated cell-cell CLPQ motif Ca2+-mediated cell-cell DNA binding Myc-Max Drosophila Helianthus annuus Magnesium chelatase C-terminal CA Cadherin AF-4 proto-oncoprotein AF4 protein GUN4 plastid GUN4-like Arabidopsis CBL N-terminus CBL receptors SH3 EF hand-like Cbl FAT-family cadherin EF hand-like Cbl FAT-family cadherin DNA binding Myc-Max Drosophila CBL N-terminus CBL receptors SH37th position alpha helix AAA VWA C-terminus Mg-Proto Mg-chelatase (Proto-oncogene AF4) (b-HLH-lz) Max DNA binding Myc-Max Drosophila (Proto-oncogene AF4) (b-HLH-lz) Max GUN4 plastid GUN4-like Arabidopsis FMR2 nuclear proteins GUN4 GUN4 plastid GUN4-like Arabidopsis DNA binding Myc-Max Drosophila GUN4 plastid GUN4-like Arabidopsis FMR2 nuclear proteins GUN4 FMR2 nuclear proteins GUN4 Cmyb_C Cyanobacterium GUN4 plastid GUN4-like Arabidopsis GUN4 plastid GUN4-like Arabidopsis7th position alpha helix AAA VWA C-terminus AT-hook domain C-myb CLPQ motif Ca2+-mediated cell-cell DNA binding Myc-Max Drosophila CBL N-terminus CBL receptors SH3 Mg-Proto Mg-chelatase Mg-chelatase catalyses insertion Mg-Proto Mg-chelatase AT-hook domain C-myb Cmyb_C Cyanobacterium Helianthus annuus Magnesium chelatase Helianthus annuus Magnesium chelatase CBL N-terminus CBL receptors SH3 Cmyb_C Cyanobacterium Mg-Proto Mg-chelatase C-terminal CA Cadherin Mg-chelatase catalyses insertion AT-hook domain C-myb FMR2 nuclear proteins GUN4 EF hand-like Cbl FAT-family cadherin

GUN4 plastid GUN4-like Arabidopsis