|
FOUR :
CUG
is the initiation
codon for one
of the two
alternative products
of the human
c-myc gene
|
: DATA
<DATA>
HGP-01313 [0, 1313, DIRECT:]
/INITIATION = CODON
EXECUTIVE SUMMARYTHEHUMANGENOMEINITIATIVEISAWORLDWIDERESEARC
LLHELPUSTOcdregion ::= sequence {TREATMANYOFTHEMORETHAN4000G
UMEROUSOTHERFIorf boolean optional ,EDWILLBECOLLECTEDINELECT
FICEOFTECHNOLOframe enumerated {NDTHENATIONALRESEARCHCOUNCIL
GRELATIONSHIPANDWInot-set (0) ,TCLOSELYWITHOTHERINTERESTEDAG
21STCENTURYANDWILLone (1) ,SEBENEFITTOTHEFIELDOFMEDICINEITWI
ANDWORKSHOPSWILLBEtwo (2) ,TOBRINGTOGETHERINVESTIGATORSWITHC
DETHECOMPARATIVEINthree (3) } default not-set ,NDINGTHEFUNCT
EPROJECTISEXPEconflict boolean optional ,MEDICALSCIENCEINTHE
OPEDTHATWILLFAgaps integer optional ,ROADRANGEOFBIOLOGICALRE
ONANDTRACKINGOmismatch integer optional ,LBEESTABLISHEDTOPRO
HESEAREAPPROPRcode genetic-code optional ,ANDSEQUENCINGGROUP
THTHISEFFORTTHcode-break sequence of code-break optional ,VI
FORMATIONINTHEstops integer optional }WTECHNOLOGYWILLBEDEVEL
H)ANDTHEDEPARTMENTOFENERGY(DOE)THETWOAGENCIESTHATHAVERECEIVE
DEARMARKEDgenetic-code ::= set of choice {VERTHELASTTWOYEARS
MAJORTASKOFTHEname visiblestring ,LREADYESTABLISHEDTHREELARG
DITIONALCENTERid integer ,FIVEYEARSTHECENTERSWILLBECOMEFOCIF
TRIALORGANIZATncbieaa visiblestring ,PLICATIONSOFTHERESEARCH
NAMELYABOUT$20ncbi8aa octet string ,OXIMATELY15YEARSFISCALYE
MOTETHECOLLABOncbistdaa octet string ,MDIVERSEDISCIPLINESONA
NTEDHEREWASPREsncbieaa visiblestring ,LINSTITUTESOFHEALTH(NI
SWILLCOALESCEAsncbi8aa octet string ,OMOSOMESORAROUNDPARTICU
TILLANTICIPATEsncbistdaa octet string }FIEDBYTHEOTAANDTHENRC
ENETICDISEASESTHATAFFLICTMANKINDASWELLASTHEMANYMULTIFACTORIA
RONICDATABcode-break ::= sequence {ATIONREADILYACCESSIBLEINC
ONVENIENTFORMTloc seq-loc ,THISREPORTDESCRIBESTHEPLANSFORTHE
THESEAGENCIESHaa choice {EDAHIGHLYSYNERGISTICANDWELLINTEGRAT
EDAPPROACHTOCARRYIncbieaa integer ,VEASEVIDENCEDBYTHEADOPTIO
NOFTHISCOMMONPLANIncbi8aa integer ,ESCIENTIFICGOALSSETOUTINT
HISREPORTANUMBEROFncbistdaa integer } }SHAVEBEENPUTINPLACEIN
ADDITIONANEWSLETTERANELECTRONICBULLETINBOARDANDACOMPREHENSIV
ICIENTTECHgenetic-code-table ::= set of genetic-codeTHISPROJ
LARMODELORGANISMSNIHANDDOEWILLCONTINUETHEIRSYNERGISTICWORKIN
EFFORTTHATimp-feat ::= sequence {ESTRUCTUREOFHUMANDNAANDDETE
EADMINISTRATIVkey visiblestring ,TUPTOFACILITATEECOMMUNICATI
OMMONRESEARCHOloc visiblestring optional ,BORATIONEXCHANGEOF
MATERIALSANDUSdescr visiblestring optional }OTOCOLSWHEREVERT
ENCIESASWELLASWITHGENOMEMAPPINGPROGRAMSINOTHERCOUNTRIESASTHE
YHAVEBEENEgb-qual ::= sequence {NUETOBEENCOURAGEDTOENSUREEFF
(NRC)IN1988INTqual visiblestring ,SIMPROVEMENTSINTECHNOLOGYF
MORESPECIFICGOval visiblestring }EFIRSTFIVEYEARSTHEPLANPRESE
ORCOLLABORATIONWITHINVESTIGATORSATOTHERLOCATIONSANDWITHINDUS
ECTATALLLErna-ref ::= sequence {NTHEADVISORYCOMMITTEESTORECE
ARS1988TO1990Htype enumerated {GETTINGORGANIZEDANDGETTINGRES
LDISEASESINWHICHGEunknown (0) ,SITIONPLAYSANIMPORTANTROLEACE
IONINGOFTHEHUMANGEpremsg (1) ,MATIONGENERATEDBYTHEHUMANGENOM
ORALMOSTEVERYASPECmrna (2) ,SRESEARCHHAVETAKENPLACEASARESULT
ECENTERSINITSNATIOtrna (3) ,ORIESANDNIHWILLESTABLISH10TO20AD
IPTOFGRANTSANDCONTrrna (4) ,ERALLBUDGETNEEDSFORTHEEFFORTARES
NTRALLYCOORDINATEDsnrna (5) ,SSEDONSPECIFICOBJECTIVESISBELIE
VEDTOBETHEMOSTEFFIscrna (6) ,STEXPENSIVEWAYOFOBTAININGTHISIN
USHUMANGENOMEPROJEother (255) } ,SEORIGINALLYPREPAREDBYTHEOF
RESULTSTHEREBYpseudo boolean optional ,LATEDPROJECTSMEETINGS
RMININGTHELOCAext choice {IMATED100000HUMANGENESINPARALLELWI
EARCHUNDERWAYTHEFIname visiblestring ,EENSPECIFIEDINTHISPLAN
YGETORGANIZEDCLOSEtrna trna-ext } optional }MEDICALLCOMMUNIT
SEARCHBRINGDOWNTHECOSTOFMANYEXPERIMENTSANDFINDAPPLICATIONINN
AREFORTHEPtrna-ext ::= sequence {5ANDASSUMETHEPROGRAMWILLRAP
IDLYREACHTHELEaa choice {GSPECIFIEDABOVE
SCIENTIFIC GOALSIIiupacaa integer ,ANGENOMEINITIATIVEISAWORL
NINGOFTHEHUMANGENOncbieaa integer ,ENERATEDBYTHEHUMANGENOMEP
TICDISEASESTHATAFFncbi8aa integer ,ASTHEMANYMULTIFACTORIALDI
ATISPRODUCEDWITHINncbistdaa integer } optional ,NWILLUNDOUBT
THERESEARCHEFFcodon set of integer optional ,TIPHASERESEARCH
EBYEARLY1990AREPORanticodon seq-loc optional }ONDUCTOFTHEHUM
ANGENOMEPROGRAMTHEFY1990HOUSEAPPROPRIATIONSCOMMITTEEREPORTAL
ROJECTISEXgene-ref ::= sequence {FORBIOMEDICALSCIENCEINTHE21
EPRIVATESECTORlocus visiblestring optional ,RAINEDMANPOWERTH
EDLYBEAMAJORTOallele visiblestring optional ,IOLOGICALRESEAR
DEVELOPMANYUSEdesc visiblestring optional ,THENEWKNOWLEDGETH
CEDTOASTAGEOFDmaploc visiblestring optional ,NREALISTICALLYB
PPROPRIATIONSBpseudo boolean default false ,EDTHENIHTOPREPAR
EDATAANDTHETECdb set of dbtag optional ,GENOMEPROGRAMANDWILL
ANDTAKINGADVANsyn set of visiblestring optional }HUMANGENOME
PROJECTISEXPECTEDTOBEOFIMMENSEBENEFITTOMEDICALSCIENCEITWILLH
CHASARESULorgname ::= sequence {NBASICRESEARCHONMOLECULARAND
EARCHCOUNCIL(Nname choice {MMENDEDTHATTHEUNITEDSTATESSUPPORT
OBOTHTHEDEPARTMENTbinomial binomialorgname ,LINSTITUTESOFHEA
SOASKEDTHENIHFORACvirus visiblestring ,LANBYTHETIMEOFTHEFY19
CLOSELYFORTHELASTThybrid multiorgname ,TOFTHEPROGRAMTHISPLAN
EPLANAPPROXIMATELYnamedhybrid binomialorgname ,TIFICDEVELOPM
DWIDERESEARCHEFFORpartial partialorgname } optional ,UREOFHU
EYWILLBEVALUABattrib visiblestring optional ,TIONANDOTHERENV
URTHERDISCUSSImod sequence of orgmod optional ,ADDITIONALWID
NT(OTA)REPORTPlineage visiblestring optional ,DANALYSISOFTHE
HEFIELDOFGENOMgcode integer optional ,TIONOFTHEOTAANDNRCREPO
RIETYOFBIOLOGImgcode integer optional ,CHASDEVELOPMENTALBIOL
OGYANDNEUROBIOLOGYdiv visiblestring optional }INGTOUNDERSTAN
DTHEUNDERLYINGMOLECULARMECHANISMSTHEANALYSISANDINTERPRETATIO
NOFTHEINFORMATIONWILLOCCUPYSCIENTISTSFORMANYYEARSTOCOMETHUST
SEASESINWHICHGENETICPREDISPOSITIONPLAYSANIMPORTANTROLENEWTEC
IRONMENTALFACTORSONHUMANGENETICMATERIALITISANTICIPATEDTHATTH
ECONTEMPLATEDBECAUSEOFTHEFARSIGHTEDTEDINVESTMENTINBASICRESEA
THISPROJECTTHEPOSSIBILITYOFINITIATINGSUCHAMAJORANDSIGNIFICAN
YCONCURREDWITHTHENRCREPORTINFISCALYEAR1988THECONGRESSOFTHEUN
INTHESCIENTIFICMANPOWERTHATWILLBEABLETOTAKEADVANTAGEOFTHEIMM
INITIATIVEWASPREPAREDBYTHEHEALTHANDENVIRONMENTALRESEARCHADVI
SCIENTIFICDEVELOPMENTSTHATHADLEDTOTHEPROMISEOFACTUALLYBEINGA
STCENTURYITWILLHAVEAPROFOUNDIMPACTONANDEXPEDITEPROGRESSINAVA
HNOLOGIESEMANATINGFROMTHEGENOMEPROJECTWILLALSOFINDAPPLICATIO
DVISORYCOMMITTEEONCOMPLEXGENOMESALSOPREPAREDIN1988ESSENTIALL
ENSEOPPORTUNITIESFORRESEARCHANDINNOVATIONTHATWILLEMANATEFROM
ITYDURING1986AND1987INTHESPRINGOF1987AREPORTONTHEHUMANGENOME
BLETOMAPANDSEQUENCETHEHUMANGENOMEANDPRESENTEDANUMBEROFOPTION
RTSANDPRESENTSAPLANFORTHEHUMANGENOMEPROGRAMWITHEMPHASISONTHE
MANDNAANDDETERMININGTHELOCATIONOFALLHUMANGENESINPARALLELWITH
THISEFFORTTHEDNAOFASETOFMODELORGANISMSWILLBESTUDIEDTOPROVIDE
HEMAXIMALBENEFITOFTHEHUMANGENOMEPROJECTWILLONLYBEACHIEVEDIFI
ITEDSTATESLAUNCHEDTHEHUMANGENOMEPROJECTBYAPPROPRIATINGFUNDST
PRESENTREPORTCONTAINSASUMMARYOFTHEPROGRESSTHATHASBEENMADEINT
NINOTHERFIELDSSUCHASAGRICULTUREANDTHEENVIRONMENTALSCIENCESTH
CLEARLYTHELEADERINTHISFIELDPURSUITOFTHEHUMANGENOMEPROJECTWIL
LALLOWTHEUSTOREMAINATTHEFOREFRONTOFBIOMEDICALSCIENCEANDTOTRA
SORYCOMMITTEE(HERAC)OFTHEDEPARTMENTOFENERGY(DOE)INEARLY1988F
OFTHEFOLLOWINGTWODECADESAREPORTTOTHEDIRECTOROFNIHBYTHEADHOCA
91APPROPRIATIONSHEARINGSPREPAREDINRESPONSETOTHOSEREQUESTSTHE
THECOMPARATIVEINFORMATIONNECESSARYFORUNDERSTANDINGTHEFUNCTIO
TISSURROUNDEDBYRESEARCHEFFORTSTHATAREFOCUSSEDONUNDERSTANDING
PLANFORACCOMPLISHINGTHEGOALOFSEQUENCINGHUMANDNAOVERTHECOURSE
RCHBYTHEFEDERALGOVERNMENTOVERTHISTIMEPERIODTHEUNITEDSTATESIS
ELYCIRCULATEDINFLUENTIALREPORTSTHEOFFICEOFTECHNOLOGYASSESSME
LTH(NIH)SPECIFICALLYFORSUPPORTOFRESEARCHEFFORTSTODETERMINETH
EESTRUCTUREOFCOMPLEXGENOMESINTHEREPORTACCOMPANYINGTHESENATEA
WASPREPAREDJOINTLYBYTHENIHANDTHEDOETHEAGENCIESPLANTOREVISETH
SASTOHOWTHEUNITEDSTATESMIGHTPURSUESUCHAPROJECTTHENATIONALRES
NEXTFIVEYEARPERIODBECAUSETHETWOAGENCIESHAVEBEENCOLLABORATING
ELPUSTOUNDERSTANDANDEVENTUALLYTREATMANYOFTHEMORETHAN4000GENE
MEDICALGENETICSINTHELASTTHIRTYTOFORTYYEARSTECHNOLOGYHASADVAN
TRESEARCHPROGRAMWASEXTENSIVELYDISCUSSEDINTHESCIENTIFICCOMMUN
ENTS PbN
/ORGANISM = HOMO SAPIENS
/CLONE = 74508
/MOTE = HUMAN
</DATA>
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